基于C30加速器的^(89)Zr制备工艺研究  

Production Process of^(89)Zr Based on C30 Cyclotron

作　　者：温凯 段菲 李光 马承伟 王晓明 赵紫宇 褚浩淼 李超 王成志 王春林 WEN Kai;DUAN Fei;LI Guang;MA Chengwei;WANG Xiaoming;ZHAO Ziyu;CHU Haomiao;LI Chao;WANG Chengzhi;WANG Chunlin(HTA Co.,Ltd.,Beijing 102413,China;CAEA Center of Excellence on Nuclear Technology Applications for Engineering and Industrialization of Radiopharmaceuticals,Beijing 102413,China;CNNC Engineering Research Center of Radiopharmaceuticals,Beijing 102413,China)

机构地区：[1]原子高科股份有限公司,北京102413 [2]国家原子能机构核技术(放射性药物工程转化)研发中心,北京102413 [3]中国核工业集团有限公司放射性药物工程技术研究中心,北京102413

出　　处：《原子能科学技术》2024年第5期1145-1151,共7页Atomic Energy Science and Technology

基　　金：国际原子能机构CRP项目(F22071)。

摘　　要：^(89)Zr具有良好的衰变特性和适宜的半衰期,在PET免疫显像领域具有广阔的应用前景。本文基于C30加速器固体靶系统设计开发了新型硬币靶,同时对^(89)Zr核素制备工艺进行了研究。将钇箔装配于硬币靶后转移至C30加速器固体靶系统辐照2~4 h,初始质子能量为16.5 MeV,采用质子束流降能器装载0.4 mm厚碳膜进行衰变处理,获得约13.8 MeV的次级束流辐照在靶片上。将辐照后的靶片装入溶靶槽,采用自主开发的自动化分离装置装载羟肟酸树脂进行靶片溶解和分离纯化,最终获得^(89)Zr核素。分析测定了^(89)Zr的放射性核纯度、放射化学纯度及元素杂质含量等质量指标。检验结果显示,^(89)Zr核素批产能可达到5 GBq,放射性核纯度大于99.9%,放射化学纯度大于97%,主要元素杂质含量均低于2.5μg/GBq。通过自主设计的直冷型硬币靶系统成功制备了质量可控的^(89)Zr核素,实现了^(89)Zr核素的规模化国内供应。Due to the good decay modes and suitable half-life,^(89)Zr is widely used in the field of immune-PET imaging.The objective is to develop a new target system suitable for cyclotron nuclide production and to obtain a new method for batch production of^(89)Zr.Herein,two kinds of coin targets were designed and developed based on C30 cyclotron solid target system,and superior coin target structures were determined through irradiation verification.The yttrium foil was assembled in the coin target plate,then irradiated by protons in C30 cyclotron for about 2-4 h.The initial proton energy was 16.5 MeV,and the proton beam was decayed by a proton beam degrader loaded with carbon films of varying thicknesses.The secondary beam of suitable proton energy irradiated the target.The irradiated yttrium foil was moved into the target dissolution tank,the stages of target dissolution,separation and purification were executed sequentially through an automatic separation apparatus loaded hydroxamic acid resin.Finally,the^(89)Zr solution was collected and tested for the radionuclide purity,radiochemical purity and element impurity contents respectively.In coin target verification,the direct-cooling coin target shows better thermal conduction properties and the yttrium foil remains intact with a nearly perfect beam shape after bombardment.It proves that the direct-cooling coin target has the ability to withstand long-term beam bombardment and satisfies the production prerequisites for^(89)Zr.A preferred range of beam energy is determined by irradiation experiments.The beam energy could be controlled within 14.5-12.4 MeV by using 0.3-0.6 mm carbon films.By this means,the radioactive impurities such as 88 Zr and 88 Y decrease significantly and the radionuclide purity of^(89)Zr is higher than 99.9%.A stable,automated process for the separation and purification of^(89)Zr is achieved by separation experiments.These test results show that the production capacity of^(89)Zr could reach 5 GBq.The radiochemical purity of^(89)Zr is higher than 97

关 键 词：^(89)Zr ^(89)Y固体靶 质子回旋加速器 核素制备 

分 类 号：TL92[核科学技术—核燃料循环与材料]