针灸关元穴治疗男性勃起功能障碍的作用机制研究  

Research on Mechanism of Acupuncture and Moxibustion on RN4 in Treatment of Erectile Dysfunction in Men

作　　者：陈璐[1] 焦琮舒 赵欣佳 范林鹃 廖莹莹 杜元灏[1,3] CHEN Lu;JIAO Congshu;ZHAO Xinjia;FAN Linjuan;LIAO Yingying;DU Yuanhao(The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center of Traditional Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Guangxi University of Chinese Medicine,Nanning 530222,China;Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381 [2]广西中医药大学,广西南宁530222 [3]陕西中医药大学,陕西咸阳712046

出　　处：《针灸临床杂志》2024年第4期1-5,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家自然科学基金面上项目,编号:82074543。

摘　　要：关元穴是目前泌尿生殖系统领域研究最为广泛的腧穴之一,也是在阴茎勃起功能障碍治疗中应用频率最高的穴位之一。针刺关元穴后,通过躯体-自主神经反射、细胞神经间突触样连接,传递生物化学信号,调控平滑肌细胞及血管内皮细胞,促使阴茎血管壁扩张、血流量增加和阴茎海绵体充血胀大;同时进一步沿着脊髓、脑水平传递神经冲动,提高中枢兴奋性。针灸通过调节下丘脑-垂体-性腺轴,促进促性腺激素释放、促黄体生成素及性激素的释放,调节性功能紊乱,还可以通过调控下丘脑-垂体-肾上腺轴来改善焦虑、抑郁情绪。此外,还可通过增强盆底肌力量、提高盆底肌肉本体感觉,改善勃起功能。然而,针刺关元穴兴奋男性阴茎勃起功能效应相关的分子生物学机制仍有待进一步完善。Guanyuan(RN4) is one of the most extensively studied acupoints in the field of urogenital system and is also one of the most frequently used acupoints in treatment of erectile dysfunction.After needling RN4,biological signals are transmitted through somatic-autonomic reflexes and synaptic-like connections between nerve cells,regulating smooth muscle cells and vascular endothelial cells,causing dilation of penile blood vessels,increased blood flow,and engorge and enlarge penile corpus cavernosum.Furthermore,nerve impulses are further transmitted along spinal cord and brain levels to enhance central excitability.Acupuncture and moxibustion regulates the hypothalamic-pituitary-gonadal axis,promotes the release of gonadotropin-releasing hormone,luteinizing hormone,and sex hormones to regulate sexual dysfunction.It can also improve anxiety and depression by regulating the hypothalamic-pituitary-adrenal axis.In addition,it can enhance pelvic floor muscle strength,improve pelvic floor muscle proprioception,and improve erectile function.However,the molecular biology mechanisms related to the stimulating effect of needling RN4 on male erectile function remain to be further elucidated.

关 键 词：勃起功能障碍 关元 躯体-自主神经反射 阴茎海绵体动脉 

分 类 号：R246.7[医药卫生—针灸推拿学]