自主研发胰腺处方粮对健康犬代谢稳态的调节作用  

Regulation of Metabolic Homeostasis in Healthy Dogs by Self-developed Pancreatic Prescription Diet

作　　者：刘媛媛 程旭 陈芸 万娟 胡曼丽 张鑫 LIU Yuanyuan;CHENG Xu;CHEN Yun;WAN Juan;HU Manli;ZHANG Xin(Gannan Innovation and Transformation Medical Research Institute,Key Laboratory of Cardiovascular Disease Prevention and Control,Ministry of Education,the First Affiliated Hospital of Gannan Medical College,Gannan Medical College,Ganzhou 341000,China;Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Shanghai 200000,China)

机构地区：[1]赣南创新与转化医学研究院,心脑血管疾病防治教育部重点实验室,赣南医学院附属第一医院,赣南医学院,赣州341000 [2]中国农业科学院上海兽医研究所,上海200000

出　　处：《实验动物科学》2024年第2期15-21,共7页Laboratory Animal Science

基　　金：广东省畜禽育种与营养研究重点实验室开放课题(2021SZ04);国家自然科学基金青年科学基金项目(82100086)。

摘　　要：目的本研究旨在制备添加富含白藜芦醇的蓝莓提取物的自研犬胰腺处方粮,并系统性地评价其对健康田园犬机体状态和代谢稳态的调节和改善作用。方法采用自研处方粮和对照饲料分别喂养健康犬8周,对实验0周和8周犬开展身体检查、全血细胞计数、血清生化检测,并收集血浆进行非靶向代谢组学检测。结果与对照组相比,自研处方粮喂养8周犬除总胆固醇降低外,其他生理生化指标未表现出异常,且血浆代谢组学分析发现自研处方粮可促进健康犬的谷胱甘肽、精氨酸代谢等过程。结论上述代谢过程被报道与胰腺炎发生明确相关,提示自研处方粮具有保护胰腺、调节代谢平衡的潜在功能。Objective This study aimed to prepare a self-developed canine pancreatic prescription diet supplemented with blueberry extract rich in resveratrol and systematically evaluate the regulation and improvement effects on healthy pastoral canine physical status and metabolic homeostasis.Method Healthy dogs fed with self-developed prescription diet or control diet for 8 weeks,respectively.Physical examination,whole blood cell count and serum biochemistry test were carried out in dogs at 0 and 8 weeks of the experiment,and plasma was collected for untargeted metabolomics analysis.Result Compared with the control group,other physiological and biochemical indicators showed no abnormalities in addition to the reduction of total cholesterol in dogs fed with self-developed prescription diet for 8 weeks.Plasma metabolomics showed that self-developed prescription diet feeding promoted glutathione and arginine metabolism in healthy dogs.Conclusion The above metabolic process has been reported to be clearly related to the occurrence of pancreatitis,suggesting the self-developed prescription diet has the potential function of protecting pancreas and regulating metabolic balance.

关 键 词：胰腺炎 胰腺处方粮 白藜芦醇 血浆代谢组学 代谢稳态 

分 类 号：Q95-3[生物学—动物学]