脊柱关节炎动物模型研究进展  

Research Progress on Spondyloarthritis Animal Models

作　　者：张景艺 王友志 杨丰钒 朱文潇 李军[4] ZHANG Jingyi;WANG Youzhi;YANG Fengfan;ZHU Wenxiao;LI Jun(Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Clinical Immunology,Xijing Hospital,the Air Force Medical University,Xi’an 710032,China;Department of Rheumatology and Immunology,Tangdu Hospital,the Air Force Medical University,Xi’an 710000,China;Rheumatology and Immune Joint Surgery,Honghui Hospital,Xi’an Jiaotong University,Xi’an 710000,China;Xi’an Electric Power Central Hospital,Xi’an 710032,China)

机构地区：[1]陕西中医药大学,咸阳712046 [2]空军军医大学西京医院临床免疫科,西安710032 [3]空军军医大学唐都医院风湿免疫科,西安710000 [4]西安交通大学附属红会医院风湿免疫关节矫形科,西安710000 [5]西安电力中心医院,西安710032

出　　处：《实验动物科学》2024年第2期96-101,共6页Laboratory Animal Science

基　　金：国家自然科学基金(81672172)。

摘　　要：脊柱关节炎(SpA)是一种常见的自身免疫性疾病,累及中轴和外周关节,主要病理特征为附着点炎、骨破坏和新骨形成。动物模型的建立将成为深入研究SpA的发生发病机制及疗法的良好载体,因此本文将为关于SpA的动物模型的研究发展做出综述,并力求为SpA动物模型的研究建立提供新思路,将进一步增强SpA动物模型的研究理论及实验基础,从而为SpA的发病机制、临床疗法的研究带来新思路。Spondyloarthritis(SpA)is a common autoimmune disease that mostly affects the axial and peripheral joints.It is characterized pathologically by enthesitis,bone breakdown,and new bone formation.The development of an animal model will provide a good platform for in-depth study of the pathogenesis and therapy of SpA,so this article will review the development of SpA animal model research and strive to provide new ideas for the study and establishment of a SpA animal model,which will further enhance the research theory and experimental basis of the SpA animal model,bringing new ideas for the study of the pathogenesis and clinical therapy of SpA.

关 键 词：脊柱关节炎(SpA) 动物模型 附着点炎 炎症 

分 类 号：Q95-3[生物学—动物学]