乙酰半胱氨酸雾化吸入辅助治疗小儿支气管肺炎的效果及对痰液炎性因子、免疫功能及肺功能的影响  

Effect of acetylcysteine aerosol inhalation in the adjuvant treatment of bronchial pneumonia in children and its influences on sputum inflammatory factors,immune function and pulmonary function

作　　者：邓当 武玲媚 叶宝妮 DENG Dang;WU Lingmei;YE Baoni(People's Hospital of Tongchuan,Tongchuan 727000,China)

机构地区：[1]铜川市人民医院,陕西铜川727000

出　　处：《临床医学研究与实践》2024年第14期41-44,共4页Clinical Research and Practice

基　　金：中华国际科学交流基金会项目(No.Z2019LSXB006)。

摘　　要：目的观察乙酰半胱氨酸雾化吸入辅助治疗小儿支气管肺炎的效果及对痰液炎性因子、免疫功能及肺功能的影响。方法选择2021年6月至2022年6月我院收治的90例支气管肺炎患儿作为研究对象,随机将其分为对照组和观察组,各45例。对照组给予盐酸氨溴索等常规治疗,观察组在对照组基础上采用乙酰半胱氨酸雾化吸入辅助治疗。比较两组的治疗效果。结果观察组的发热、咳嗽、肺部啰音、喘息消失时间短于对照组(P<0.05)。治疗后,两组的肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及肺表面活性蛋白D(SP-D)水平均降低,且观察组低于对照组(P<0.05)。治疗后,两组的调节性T细胞(Treg)均升高,辅助性T细胞17(Th17)及补体C3、C4水平均降低,且观察组优于对照组(P<0.05)。治疗后,两组的用力肺活量(FVC)、每分钟最大通气量(MVV)及最大呼气流速峰值(PEF)均升高,且观察组高于对照组(P<0.05)。结论乙酰半胱氨酸雾化吸入辅助治疗小儿支气管肺炎具有更好效果,可促进患儿症状改善,降低炎症反应,提高免疫功能,有效改善肺功能。Objective To observe the effect of acetylcysteine aerosol inhalation in the adjuvant treatment of bronchial pneumonia in children and its influences on sputum inflammatory factors,immune function and pulmonary function.Methods A total of 90 children with bronchial pneumonia admitted in our hospital from June 2021 to June 2022 were selected as the research objects and randomly divided into control group and observation group,with 45 cases in each group.The control group was given routine treatment such as ambroxol hydrochloride,and the observation group was treated with acetylcysteine aerosol inhalation on the basis of the control group.The therapeutic effects of the two groups were compared.Results The disappearance time of fever,cough,pulmonary rales and wheezing in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)and surfactant protein D(SP-D)in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the regulatory T cells(Treg)in the two groups increased,the T-helper type 17(Th17)and complement C3 and C4 levels decreased,and those in the observation group were better than the control group(P<0.05).After treatment,the forced vital capacity(FVC),maximal voluntary ventilation(MVV)and peak expiratory flow(PEF)in the two groups increased,and those in the observation group were higher than the control group(P<0.05).Conclusion Acetylcysteine aerosol inhalation in the adjuvant treatment of bronchial pneumonia in children has a better effect,which can promote the improvement of symptoms,reduce inflammation,enhance immune function and effectively improve pulmonary function.

关 键 词：小儿支气管肺炎 乙酰半胱氨酸 盐酸氨溴索 炎性因子 免疫功能 肺功能 

分 类 号：R563.1[医药卫生—呼吸系统]