嗜酸粒细胞性慢性鼻窦炎及A20的研究进展  

Research progress on eosinophilic chronic rhinosinusitis and A20

作　　者：江青山[1] 余静 唐洪波[1] JIANG Qingshan;YU Jing;TANG Hongbo(Otorhinolaryngology Department,the First Affiliated Hospital of University of South China,Hengyang 421001;General Thoracic and Thyroid Surgery Department,Yueyang Central Hospital,Yueyang 414000,China)

机构地区：[1]南华大学附属第一医院耳鼻咽喉科,湖南衡阳421001 [2]湖南省岳阳市中心医院普胸甲状腺外科,湖南岳阳414000

出　　处：《临床医学研究与实践》2024年第15期191-194,共4页Clinical Research and Practice

基　　金：2020年度湖南省临床医疗技术创新引导项目(No.2020SK51803)。

摘　　要：慢性鼻窦炎(CRS)是一种鼻腔鼻窦慢性炎症性疾病,其中嗜酸粒细胞性CRS术后的复发率可接近50%,且嗜酸性粒细胞浸润较明显,与核因子κB(NF-κB)通道激活有关。本文综述锌指蛋白A20的结构特征、生物功能及与炎症、肿瘤相关疾病的关系,认为其作为NF-κB的负性调控因子参与了多种炎症及肿瘤疾病,发挥抑制炎症和肿瘤疾病的作用,为高复发率的嗜酸粒细胞性CRS诊疗提供新的思路。Chronic rhinosinusitis(CRS)is a chronic inflammatory disease of the nasal cavity and paranasal sinuses.The recurrence rate of eosinophilic CRS after surgery can be close to 50%,and the infiltration of eosinophils is obvious,which is related to the activation of nuclear factor-κB(NF-κB)channels.This article reviews the structural characteristics,biological functions,and relationship with inflammation and tumor related diseases of zinc finger protein A20.Consider it as a negative regulatory factor of NF-κB is involved in multiple inflammatory and tumor diseases,playing a role in inhibiting inflammation and tumors,providing new ideas for the diagnosis and treatment of high recurrence rate eosinophilic CRS.

关 键 词：慢性鼻窦炎 嗜酸性粒细胞 A20 核因子ΚB 炎症 肿瘤 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]