H-FABP与BNP在快速心房纤颤诊断与评估中的应用  

Application of heart-type fatty acid-binding protein and pro-B-type natriuretic peptide in the diagnosis and evaluation of rapid atrial fibrillation

作　　者：高翔 李伟真 于立涛 刘艳 郑晓静[2] GAO Xiang;LI Wei-zhen;YU Li-tao;LIU Yan;ZHENG Xiao-jing(The People's Hospital of Fangzi District,Weifang 261200,China;The Affiliated Hospital of Weifang Medical University,Weifang 261031,China)

机构地区：[1]山东省潍坊市坊子区人民医院,山东潍坊261200 [2]潍坊医学院附属医院,山东潍坊261031

出　　处：《心血管病防治知识（学术版）》2024年第1期42-45,共4页Prevention and Treatment of Cardiovascular Disease

基　　金：潍坊市科技发展计划项目任务书(医学类)项目编号:2021yx104,项目负责人:高翔。

摘　　要：目的旨在研究心脏型脂肪酸结合蛋白(H-FABP)与前体B型钠尿肽(pro-BNP)在快速心房纤颤(简称房颤)中的诊断和评估价值。方法应用双抗夹心酶联免疫吸附试验(ELISA)对2021年1月至2022年12月间,潍坊市坊子区人民医院急诊收治的79例快速房颤患者的血浆中H-FABP和pro-BNP进行检测。进一步结合患者的临床表现、心功能检测进行综合分析。结果在阵发性、持续性和永久性房颤患者中,血浆H-FABP的平均含量分别为(7.0±1.7)ng/mL、(8.3±2.2)ng/mL和(9.5±3.0)ng/mL,而pro-BNP的平均含量则分别为(819±125)pg/mL、(1630±215)pg/mL和(2189±165)pg/mL。阵发性房颤患者经过胺碘酮转复心律后,H-FABP和pro-BNP水平均显著下降至(6.2±1.1)ng/mL和(561±117)pg/mL。根据NYHA心功能分级,Ⅲ级和Ⅳ级患者的H-FABP和pro-BNP含量显著高于心功能较好的患者。结论H-FABP和pro-BNP的血浆水平与快速房颤患者的心功能状态显著关联,因此有潜力作为房颤诊断和心功能评估的生物标志物。Objective To investigate the value of heart-type fatty acid-binding protein(H-FABP)andpro-B-type natriuretic peptide(proBNP)in the diagnosis and evaluation of rapid atrial fibrillation. Methods A total of 79 patients with rapid atrial fibrillation who were admitted to Department of Emergency,The People's Hospital of Fangzi District,from January 2021 to December 2022 were enrolled,and double-antibody sandwich enzyme-linked immunosorbent assay was used to measure the plasma levels of H-FABP and proBNP.A comprehensive analysis was performed based on clinical manifestation and cardiac function testing. Results The mean level of plasma H-FABP was(7.0±1.7)ng/mL in patients with paroxysmal atrial fibrillation,(8.3±2.2)ng/mL in patients with persistent atrial fibrillation,and 9.5±3.0 ng/mL in patients with permanent atrial fibrillation,while the mean level of proBNP in these three groups of patients was(819±125)pg/mL,(1630±215)pg/mL,and(2189±165)pg/mL,respectively.For the patients with paroxysmal atrial fibrillation,the levels of H-FABPand proBNP were reduced significantly to(6.2±1.1)ng/mL and(561±117)pg/mL,respectively,after cardioversion with amiodarone.Based on NYHA classification for cardiac function,the patients with grade III/IV cardiac function had significantly higher levels of H-FABPand proBNP than those with good cardiac function. Conclusion The plasma levels of H-FABPand proBNP are significantly associated with the cardiac function of patients with rapid atrial fibrillation,and therefore,they can be used as potential biomarkers for the diagnosis of atrial fibrillation and the evaluation of cardiac function.

关 键 词：心房纤颤 H-FABP PRO-BNP 心功能状态 

分 类 号：R541.75[医药卫生—心血管疾病]