基于ICP-MS/MS测定中药白扁豆中18种无机元素及其质量评价  

Determination and Quality Evaluation of 18 Inorganic Elements in Semen Lablab Album Based on ICP-MS/MS

作　　者：戚鹏飞 王月玲 邵长春 李洁 张晓萍 季申 朱仁愿 QI Pengfei;WANG Yueling;SHAO Changchun;LI Jie;ZHANG Xiaoping;JI Shen;ZHU Renyuan(Lanzhou Institute for Food and Drug Testing,Key Laboratory of Controlling Pesticide and Veterinary Drug Residues in Food for State Market Regulation,Gansu Lanzhou 730050,China;Shanghai Institute for Food and Drug Control,NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine,Shanghai 200240,China)

机构地区：[1]兰州市食品药品检验检测研究院,国家市场监管重点实验室(食品中农药兽药残留监控),甘肃兰州730050 [2]上海市食品药品检验研究院,国家药品监督管理局中药质量控制重点实验室,上海200240

出　　处：《中国医药导刊》2024年第3期248-253,共6页Chinese Journal of Medicinal Guide

基　　金：甘肃省药品监督管理局药品科研项目(2022GSMPA0069);兰州市科学技术局兰州市科技计划项目(2022-2-45)。

摘　　要：目的:采用串联四级杆电感耦合等离子体质谱法(ICP-MS/MS)测定中药白扁豆中18种无机元素的含量,结合化学计量学分析不同产地及性状差异白扁豆的质量情况。方法:采用超级微波消解处理样品后,采用串联四级杆电感耦合等离子体质谱法进行测定,对测定结果进行主成分分析及聚类分析。结果:测定的各无机元素线性关系良好;主成分分析得到6个主成分,累计方差贡献率达到83.959%;确定锰(Mn)、镍(Ni)、铜(Cu)、锶(Sr)、钴(Co)、硒(Se)、铷(Rb)、钡(Ba)、铬(Cr)、镉(Cd)、银(Ag)、锂(Li)、铍(Be)、钒(V)、铅(Pb)等15种元素为白扁豆的主要特征元素。结论:该方法操作简便、结果准确、灵敏度高,可用于中药白扁豆中无机元素的测定,为进一步研究中药白扁豆提供了参考。Objective:To determine the contents of 18 inorganic elements in Semen Lablab Album by inductively coupled plasma tandem mass spectrometry(ICP-MS/MS),and to analyze the quality of Semen Lablab Album with different origin and character difference by stoichiometry.Methods:After ultra microwave digestion,the samples were determined by quadrupole inductively coupled plasma mass spectrometry.The results were analyzed by principal component analysis and cluster analysis.Results:The linear relationship of each inorganic element was good.Six principal components were obtained by principal component analysis,and the cumulative variance contribution rate was 83.959%.The results showed that Mn、Ni、Cu、Sr、Co、Se、Rb、Ba、Cr、Cd、Ag、Li、Be、V、Pb are the main characteristic elements of Semen Lablab Album.Conclusion:The method is simple,accurate and sensitive.It can be used for the determination of inorganic elements in Semen Lablab Album,and provides a reference for further study of Semen Lablab Album.

关 键 词：ICP-MS/MS 白扁豆 无机元素 主成分分析 

分 类 号：R284.1[医药卫生—中药学]