维生素A、维生素E水平与儿童喘息性疾病的相关性研究  

Correlations of vitamin A and vitamin E levels with wheezing disease in children

作　　者：张敏[1] 温志红[1] 杨彩婷 张迪雯 ZHANG Min;WEN Zhihong;YANG Caiting;ZHANG Diwen(Department of Pediatrics,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China;Department of Pediatrics,Guangxi Hospital Division of the First Affiliated Hospital,Sun Yat-sen University,Nanning 530021,Guangxi,China)

机构地区：[1]广西壮族自治区人民医院儿科,南宁市530021 [2]中山大学附属第一医院广西医院儿科,南宁市530021

出　　处：《内科》2024年第2期113-116,共4页Internal Medicine

基　　金：广西壮族自治疗区卫生健康委员会自筹经费科研课题(Z20170360);广西南宁市青秀区科技计划项目(2019031)。

摘　　要：目的探讨维生素A、维生素E水平与儿童喘息性疾病的相关性。方法选取234例喘息性疾病患儿作为喘息组,另选取同期244例健康体检儿童作为对照组。比较两组维生素A、维生素E水平,并应用Pearson或Spearman相关性分析维生素A、维生素E水平与喘息组肺功能的相关性。结果喘息组维生素A水平、维生素A正常者占比均低于对照组,亚临床维生素A缺乏者占比和可疑亚临床维生素A缺乏者占比均高于对照组(均P<0.05)。喘息组维生素E水平、维生素E正常者占比均低于对照组,维生素E缺乏者占比和维生素E不足者占比均高于对照组(均P<0.05)。Pearson相关性分析结果显示,维生素A水平与达峰时间比、达峰容积、呼出气一氧化氮(FeNO)、免疫球蛋白(Ig)E、IgG和外周血嗜酸性粒细胞(EOS)绝对值均无相关性(均P>0.05)。维生素E水平与达峰时间比、达峰容积、IgE、IgG和外周血EOS绝对值也无相关性(均P>0.05),但与FeNO呈负相关(P<0.05)。结论喘息性疾病患儿的维生素A、维生素E水平较低,且维生素E水平与FeNO呈负相关。Objective To investigate the correlations of vitamin A and vitamin E levels with wheezing disease in children.Methods A total of 234 children with wheezing disease were selected as the wheezing group,while 244 children undergoing healthy physical examinations were selected as the control group.The vitamin A and vitamin E levels were compared between the two groups,and their correlations with lung function in the wheezing group were analyzed with Pearson or Spearman correlation.Results The vitamin A level and the proportion of children with normal vitamin A levels in the wheezing group were lower than those in the control group,and the proportions of children with subclinical vitamin A deficiencies and children with suspected subclinical vitamin A deficiencies were higher than those in the control group(all P<0.05).The vitamin E level and the proportion of children with normal vitamin E levels in the wheezing group were lower than those in the control group,and the proportions of children with vitamin E deficiencies and children with vitamin E insufficiencies were higher than those in the control group(all P<0.05).The results of Pearson correlation analysis showed that there was no correlation between the vitamin A level and ratio of time to peak tidal expiratory flow to total expiratory time,volume at peak tidal expiratory flow,fractional exhaled nitric oxide(FeNO),immunoglobulin(Ig)E,IgG,or the absolute value of peripheral blood eosinophils(EOS)(all P>0.05).There was no correlation between the vitamin E level and ratio of time to peak tidal expiratory flow to total expiratory time,volume at peak tidal expiratory flow,IgE,IgG,or the absolute value of peripheral blood EOS(all P>0.05),but there was negative correlation between the vitamin E level and FeNO(P<0.05).Conclusion Vitamin A and vitamin E levels in children with wheezing disease are relatively low,and their vitamin E levels are negatively correlated with FeNO.

关 键 词：喘息性疾病 儿童 维生素A 维生素E 

分 类 号：R725.6[医药卫生—儿科]