α-促黑素细胞激素在皮肤病治疗中的研究进展  

Research Progress of Alpha-Melanocyte Stimulating Hormone in the Treatment of Dermatosis

作　　者：赵茜雅 李俊琴[2] 李新华[2] ZHAO Qianya;LI Junqin;LI Xinhua(Ninth Clinical College of Medicine,Shanxi Medical University,Taiyuan 030009,China;Department of Dermatology and Key Laboratory of Stem Cells for Immune Skin Diseases,Taiyuan Central Hospital,Shanxi Medical University,Taiyuan 030009,China)

机构地区：[1]山西医科大学附属第九临床医学院,山西太原030009 [2]山西医科大学附属太原市中心医院皮肤科及免疫性皮肤病干细胞重点实验室,山西太原030009

出　　处：《皮肤科学通报》2024年第2期220-224,共5页Dermatology Bulletin

基　　金：中央引导地方科技发展专项资金项目(YDZX20191400004470);山西省医学重点科研项目(2020XM20)。

摘　　要：α-促黑素细胞激素是一种神经内分泌激素,主要负责刺激毛发和皮肤中黑色素的产生。另外,它在控制食欲和能量平衡、性行为和缺血再灌注相关损伤等方面也发挥着重要作用。近年来,人们对开发α-促黑素细胞激素类似物有着很大的兴趣,并且已经初步用于治疗卟啉病、白癜风、家族性良性慢性天疱疮、多形性日光疹、日光性荨麻疹、寻常性痤疮等皮肤病。本文综述了α-促黑素细胞激素在皮肤病中的作用机制和治疗应用。Alpha-melanocytotropic hormone is a neuroendocrine hormone primarily responsible for stimulating the production of melanin in hair and skin.It also plays a role in controlling appetite and energy balance,sexual behavior,and ischemia-reperfusion-related injuries.In recent years,there has been considerable interest in the development of alpha-melanocyte hormone analogues.At the same time,they have been initially used in the treatment of porphyria,vitiligo,familial benign chronic pemphigus,polymorphous light eruption,solar urticaria,acne vulgaris and other skin diseases.This article reviews the mechanism and therapeutic application of alpha-melanocytotropic hormone in dermatosis.

关 键 词：Α-促黑素细胞激素 皮肤病 治疗 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]