精氨酸代谢对肿瘤生长及肿瘤免疫的影响  

Effect of arginine metabolism on tumor growth and tumor immunity

作　　者：李玖炎 雷连成 黄晶[1] Jiuyan;LEI Liancheng;HUANG Jing(Department of Clinical Laboratory,the First Hospital of Jilin Univer-sity,Changchun 130021,China;College of Veterinary Medicine,Jilin University,Changchun 130062,China)

机构地区：[1]吉林大学第一医院检验科,长春130021 [2]吉林大学动物医学学院,长春130062

出　　处：《中国免疫学杂志》2024年第5期999-1009,共11页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(31772715)。

摘　　要：氨基酸代谢在疾病发生发展中的重要性逐渐被认知,其中精氨酸代谢与肿瘤的关系已成为研究热点。精氨酸作为条件性必需氨基酸,在肿瘤的发生、生长、转移过程中发挥重要作用。肿瘤免疫抑制性微环境的形成以及髓系免疫细胞的表型变化、成熟程度和功能状态都与精氨酸代谢密不可分。本文针对国内外上述相关研究成果,主要总结了精氨酸代谢在肿瘤生长、抗肿瘤免疫中的作用,归纳了肿瘤免疫微环境中的髓系免疫细胞类型、功能以及靶向精氨酸代谢途径的肿瘤治疗策略。The importance of amino acid metabolism has been gradually recognized,and the relationship between arginine metabolism and tumors has become a hot topic.Arginine is a conditionally essential amino acid,which is closely related to the occurrence,growth and metastasis of tumors.The formation of an immunosuppressive microenvironment,and the phenotypic changes,maturation and functional status of myeloid immune cells are also inseparable from arginine metabolism.This article mainly elucidates how arginine metabolism affects tumors and the role of arginine in anti-tumor immunity,summarizes the main myeloid immune cells in the tumor microenvironment,and briefly summarizes the tumor treatment strategies that target the arginine metabolism pathway.

关 键 词：精氨酸代谢 肿瘤 肿瘤免疫 

分 类 号：R392.1[医药卫生—免疫学]