幽门螺杆菌定植强度与不同程度慢性胃炎之间的相关性  

Correlation between Helicobacter pylori colonization intensity and different degrees of chronic gastritis

作　　者：黄亚芳 江贵 刘冠茜 郭元怡 陈润花[2] HUANG Yafang;JIANG Gui;LIU Guanxi;GUO Yuanyi;CHEN Runhua(Beijing University of Chinese Medicine,Beijing 100029;Department of Spleen,Stomach,Liver and Gallbladder,Dongfang Hospital,Beijing University of Chinese Medicine,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院脾胃肝胆科

出　　处：《胃肠病学和肝病学杂志》2024年第5期509-512,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：北京中医药大学校级科研纵向发展基金(2021-ZXFZJJ-035)。

摘　　要：目的探讨H.pylori定植强度与慢性胃炎的严重程度、活动强度及组织病理学变化的相关性。方法回顾性分析2021年6月至2023年2月在北京中医药大学东方医院行胃镜检查患者病历资料,根据病理学检查结果分为H.pylori定植轻、中、重度组,分析三组人群的性别、慢性胃炎严重程度、慢性胃炎活动强度和组织病理学变化的差异。结果性别与H.pylori定植强度差异无统计学意义(P=0.481)。慢性胃炎的活动强度随H.pylori定植强度的增加而增加(P<0.001)。慢性胃炎的严重程度随H.pylori定植强度的增加而增加(P<0.001)。随着H.pylori定植程度的增加,淋巴滤泡的形成、间质充血、黏膜糜烂、黏膜溃疡及肠上皮化生的可能性增加(P<0.05)。结论H.pylori定植强度增加可能会加重慢性胃炎,应将减少H.pylori定植作为健康目标。Objective To explore the correlation between the colonization intensity of H.pylori and the severity,activity intensity,and histopathological changes of chronic gastritis.Methods A retrospective analysis of medical records of patients who underwent gastroscopy at Dongfang Hospital,Beijing University of Chinese Medicine from Jun.2021 to Feb.2023 was conducted.According to the results of pathological examination,patients were divided into groups of mild,moderate,and severe H.pylori colonization,and the differences in gender,severity of chronic gastritis,activity intensity of chronic gastritis,and histopathological changes among the three groups were analyzed.Results There was no statistically significant difference in gender and H.pylori colonization intensity(P=0.481).The activity intensity of chronic gastritis increased with the increase of H.pylori colonization intensity(P<0.001).The severity of chronic gastritis increased with the increase of H.pylori colonization intensity(P<0.001).With the increase of H.pylori colonization degree,the possibility of formation of lymphoid follicles,interstitial congestion,mucosal erosion,mucosal ulceration,and intestinal metaplasia increased(P<0.05).Conclusion The increase in H.pylori colonization intensity may exacerbate chronic gastritis,and reducing H.pylori colonization should be considered as a health goal.

关 键 词：幽门螺杆菌 定植强度 慢性胃炎 

分 类 号：R378[医药卫生—病原生物学]