IVUS引导下观察速效救心丸对稳定型心绞痛患者冠状动脉扩张的影响  

To observe effect of Suxiao Jiuxin pill on coronary artery dilatation in patients with stable angina pectoris under intravascular ultrasound(IVUS)guidance

作　　者：宋涛 马骏[2] 沈祥礼 何金玲 史艳红 姜述斌[2] SONG Tao;MA Jun;SHEN Xiangli;HE Jinling;SHI Yanhong;JIANG Shubin(The Fourth Clinical Medical College of Xinjiang Medical University;Department of Coronary Heart Disease Intensive Care of the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学第四临床医学院 [2]新疆医科大学附属中医医院冠心病重症监护科,乌鲁木齐830000

出　　处：《新疆医科大学学报》2024年第5期694-698,共5页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金项目(2023D01C138)。

摘　　要：目的血管内超声(Intravascular ultrasound,IVUS)引导下观察速效救心丸对稳定型心绞痛患者冠状动脉扩张影响。方法以2022年5月-2024年1月新疆医科大学附属中医医院冠心病重症监护科收治的116例稳定型心绞痛患者为研究对象,随机分为试验组及对照组,每组58例。试验组舌下含服速效救心丸10粒,对照组舌下含服硝酸甘油片0.5 mg,在服药前及服药15 min后均行IVUS检查,记录服药前血管平均直径2.00、2.25、2.50、2.75、3.00、3.25、3.50 mm处的横截面积,计算服药后15 min相应血管位置的血管横截面积、面积扩张百分比及平均血管直径,记录患者在服药及检查后头晕、头痛、血压降低、面红、恶心等不良反应的发生情况。结果与本组服药前相比,服药后15 min对照组冠状动脉在2.00 mm~3.5 mm直径血管的横截面积及平均直径增大,试验组冠状动脉在2.00 mm~2.75 mm直径血管的横截面积增大,在2.00 mm~3.00 mm直径血管的平均直径增大,差异有统计学意义(P<0.05)。与对照组服药后15 min比较,试验组服药后15 min在直径2.00 mm血管的横截面积、面积扩张百分比及平均直径增大,在2.75 mm~3.50 mm直径血管的横截面积、面积扩张百分比及平均直径减小,差异有统计学意义(P<0.05)。与对照组比较,试验组患者不良反应发生率降低,差异有统计学意义(P<0.05)。结论速效救心丸对稳定型心绞痛患者冠状动脉有扩张的作用,血管直径越小扩张作用越明显,不良反应发生率低。Objective To observe the effect of Suxiao Jiuxin pill on coronary artery dilation in patients with stable angina pectoris guided by intravascular ultrasound(IVUS).Methods A total of 116 patients with stable angina pectoris admitted to the hospital from May 2022 to January 2024 were studied,the patients were randomly divided into experimental group and control group,58 cases in each group.The experimen-tal group was given sublingual 10 capsules of Suxiao Jiuxin pill,the control group was given sublingual 0.5 mg nitroglycerin tablet.IVUS examination was performed before and 15 minutes after medication.Recorded the cross-sectional area at 2.00 mm,2.25 mm,2.50 mm,2.75 mm,3.00 mm,3.25 mm and 3.50 mm mean vessel diameters prior to medication.The vessel cross-sectional area,the percentage of area expansion and the average vessel diameter at the corresponding blood vessel position were recorded and calculated 15 min after taking the medication.The patients were recorded for dizziness,headache,blood pressure reduction,redness,nausea and other adverse reactions after medication and examination.Results Compared with control group before taking the drug,the cross-sectional area and average diameter of the vessels in the 2.00 mm~3.5 mm diameter of the coronary arteries in the control group were increased 15 min after taking the drug.The cross-sectional area of vessels with diameter of 2.00 mm~2.75 mm and the mean diameter of vessels with diameter of 2.00 mm~3.00 mm wereincreased in the experimental group,and the difference was statistically significant(P<0.05).Compared with control group 15 min after administration,the cross-sectional area,percentage of area expansion and average diameter of vessels with a diameter of 2.00 mm wasincreased in the experimental group 15 min after administration,and the cross-sectional area,percentage of area expansion and average diameter of blood vessels with a diameter of 2.75 mm to 3.50 mm wasdecreased,with statistical significance(P<0.05).Compared with control group,the incidence of adverse

关 键 词：速效救心丸 冠状动脉 血管内超声 稳定型心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]