反刍动物抗蠕虫药研究进展  

Research Progress on Anthelmintic Drugs in Ruminants

作　　者：姚学强 李江 王娟 周凯仁 申涵露 张继瑜[1] 周绪正[1] YAO Xueqiang;LI Jiang;WANG Juan;ZHOU Kairen;SHEN Hanlu;ZHANG Jiyu;ZHOU Xuzheng(Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences,Lanzhou 730050,China)

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,兰州730050

出　　处：《中国草食动物科学》2024年第3期66-71,共6页China Herbivore Science

基　　金：甘肃省科技计划项目(20JR10RA023);国家重点研发计划项目(2022YFD16022)。

摘　　要：寄生虫病在反刍动物中广泛流行,给畜牧业造成了严重损失,临床通常使用化学疗法来防治。但由于抗寄生虫药物的不合理使用,导致耐药性问题在畜牧业中愈发严重,给公共卫生安全和反刍动物养殖业健康发展带来了极大的挑战。选用高效、广谱、低毒、投药方便、价格低廉、低残留和不易产生耐药性的抗寄生虫药是治疗动物寄虫病的基础,而通过联合用药、穿梭用药和轮换用药的方式,可维持和延长驱虫药的药效。文章基于世界各地反刍动物蠕虫病的现有流行病学研究,分析了反刍动物蠕虫病的流行现状、危害以及抗蠕虫药的应用现状与发展趋势,为反刍动物蠕虫病的药物研发提供参考。Parasitic infections are widely prevalent in ruminants,causing serious losses to animal husbandry,and people usually use chemotherapy to prevent and control them.However,due to the unreasonable use of insecticides,the problem of insecticide resistance(AR)has become increasingly serious in animal husbandry,posing great challenges to public health safety and the healthy development of ruminant breeding.The selection of highly efficient,broadspectrum,low toxicity,convenient administration,low price,low residue,and resistant antiparasitic drugs is the foundation for treating animal helminthiasis.By combining,shuttle,and rotating medication,the efficacy of antiparasitic drugs can be maintained and extended.This article was based on existing epidemiological studies on ruminant helminthiasis around the world,discussing the epidemic status and harm of ruminant helminthiasis,as well as the current status and development trends of anti worm drugs,providing insights for drug research and development of ruminant helminthiasis.

关 键 词：反刍动物 蠕虫病 抗蠕虫药 耐药性 

分 类 号：R978.63[医药卫生—药品]