Astrocytes integrate time and space  

作　　者：Justin Lines 

机构地区：[1]Department of Biological Sciences,Columbia University,New York,NY,USA

出　　处：《Neural Regeneration Research》2025年第2期467-468,共2页中国神经再生研究（英文版）

基　　金：supported by NIH-NIA (1F31AG057155-01A1);University of Minnesota Doctoral Dissertation Fellowship (to JL)

摘　　要：Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.

关 键 词：GRADED INTEGRATE instead 

分 类 号：R338[医药卫生—人体生理学]