抗体清除血液净化技术治疗抗中性粒细胞胞质抗体相关血管炎的研究进展  

Progress in treatment of anti-neutrophil cytoplasmic antibody-associated vasculitis by antibody-clearance blood purification technology

作　　者：杨悦(综述) 葛永纯(审校) YANG Yue;GE Yongchun(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210016,China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院)国家肾脏疾病临床医学研究中心,南京210016

出　　处：《肾脏病与透析肾移植杂志》2024年第2期182-186,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：抗中性粒细胞胞质抗体相关血管炎(AAV)是一类累及多系统的自身免疫性疾病,有较高的病死率和进展至终末期肾病的风险。体外循环血液净化技术已成为除糖皮质激素和免疫抑制剂之外治疗AAV的重要辅助手段,包括血浆置换、双重滤过血浆置换和免疫吸附。本文系统综述了抗体清除血液净化技术治疗AAV的研究进展以及指南推荐的变化,为临床应用提供参考。Anti-neutrophil cytoplasmic antibody-associated vasculitis(AAV)is a multisystem autoimmune disease with a high mortality and risk of progresses to end-stage kidney disease(ESKD).In addition to glucocorticoids and immunosuppressants,extracorporeal blood purification techniques have become essential adjuncts for the treatment of AAV,including plasma exchange,double-filtration plasmapheresis and immunoadsorption.In this study,the progress of antibody scavenging blood purification technology in the treatment of AAV and the changes of guidelines were systematically reviewed,so as to provide a reference for clinical treatment.

关 键 词：抗中性粒细胞胞质抗体相关血管炎 血浆置换 双重滤过血浆置换 免疫吸附 抗体清除 

分 类 号：R593.2[医药卫生—内科学] R692.5[医药卫生—临床医学]