贯叶金丝桃二氯甲烷部位的化学成分研究  

Chemical constituents of dichloromethane fraction from Hypericum perforatum

作　　者：张亦云 韩竹箴[3] 张倩 王佳 程明赛 王振中[1,2,4] 杨颖博 肖伟 ZHANG Yi-yun;HAN Zhu-zhen;ZHANG Qian;WANG Jia;CHENG Ming-sai;WANG Zhen-zhong;YANG Ying-bo;XIAO Wei(Kanion School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China;National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Lianyungang 222001,China;Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China)

机构地区：[1]南京中医药大学康缘中药学院,江苏南京210023 [2]中药制药过程控制与智能制造技术全国重点实验室,江苏连云港222001 [3]上海中医药大学中药研究所,上海201203 [4]江苏康缘药业股份有限公司,江苏连云港222001

出　　处：《中成药》2024年第5期1552-1558,共7页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局“岐黄学者”中医药领军人才项目[国中医药人教函(2021)203号]。

摘　　要：目的研究贯叶金丝桃Hypericum perforatum L.二氯甲烷部位的化学成分。方法贯叶金丝桃二氯甲烷部位采用硅胶、ODS、Sephadex LH-20、半制备HPLC等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到11个化合物,分别鉴定为贯叶金丝桃降碳聚酮A(1)、α-芒柄花醇(2)、(3 R)-thunberginol(3)、2-geranyloxy-1-(2-methylpropanoyl)-phloroglucinol(4)、4,6-dihydroxy-2-O-(3″,7″-dimethyl-2″,6″-octadienyl)-1-(2′-methylbutanoyl)benzene(5)、norhyperpalum G(6)、garsubellin A(7)、garsubellin B(8)、(2″R/S)-kellerine C(9)、kobusone(10)、圣草酚(11)。结论化合物1为新化合物,化合物2~3为首次在藤黄科植物中分离得到,化合物4~10为首次从该植物中分离得到。AIM To study the chemical constituents of dichloromethane fraction from Hypericum perforatum L.METHODS The dichloromethane fraction from H.perforatum was isolated and purified by silica gel,ODS,Sephadex LH-20,semi-preparative HPLC and etc.The structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Eleven compounds were isolated and identified as hypernorpoleketone A(1),α-onocerin(2),(3 R)-thunberginol C(3),2-geranyloxy-1-(2-methylpropanoyl)-phloroglucinol(4),4,6-dihydroxy-2-O-(3″,7″-dimethyl-2″,6″-octadienyl)-1-(2′-methylbutanoyl)benzene(5),norhyperpalum G(6),garsubellin A(7),garsubellin B(8),(2″R/S)-kellerine C(9),kobusone(10),eriodictyol(11).CONCLUSION Compound 1 is a new compound.Compounds 2-3 are isolated from the plants of family Guttiferae for the first time.Compounds 4-10 are isolated from this plant for the first time.

关 键 词：贯叶金丝桃 二氯甲烷部位 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]