调经止痛丸对子宫内膜异位症气滞血瘀证患者腹腔镜术后CA125的影响  

Effects of Tiaojing Zhitong Pill on CA125 in patients with endometriosis of qi stagnation and blood stasis pattern after laparoscopic surgery

作　　者：陈秀英[1] 陈娜[1] 崔建涛 高娜[1] 翟倩 卞欣 张士表[1] CHEN Xiuying;CHEN Na;CUI Jiantao;GAO Na;ZHAI Qian;BIAN Xin;ZHANG Shibiao(The First Obstetrics Department,Cangzhou Hospital of Integrated Chinese and Western Medicine,Cangzhou,Hebei 061000,China)

机构地区：[1]河北省沧州中西医结合医院妇一科,河北沧州061000

出　　处：《湖南中医药大学学报》2024年第5期817-821,共5页Journal of Hunan University of Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2020486)。

摘　　要：目的观察调经止痛丸对子宫内膜异位症(endometriosis,EMS)气滞血瘀证患者腹腔镜术后临床症状及癌胚抗原125(carcinoembryonic antigen 125,CA125)的影响。方法选取河北省沧州中西医结合医院120例接受腹腔镜手术治疗的EMS气滞血瘀证患者,随机分为对照组和观察组,各60例。对照组术后予以常规西药进行治疗,观察组在对照组基础上服用调经止痛丸,连续治疗6个月。比较两组临床疗效、中医证候积分、血清CA125、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平及不良反应。结果观察组总有效率96.67%,高于对照组85.00%(P<0.05);观察组治疗后中医证候积分及CA125、TNF-α水平显著低于对照组(P<0.01);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论调经止痛丸可有效减轻EMS气滞血瘀证患者腹腔镜术后临床症状,改善TNF-α及CA125水平。Objective To observe the effects of Tiaojing Zhitong Pill(TJZTP)on clinical symptoms and carcinoembryonic antigen 125(CA125)in patients with endometriosis(EMS)of qi stagnation and blood stasis pattern after laparoscopic surgery.Methods A total of 120 patients with EMS of qi stagnation and blood stasis pattern who underwent laparoscopic surgery in Cangzhou Hospital of Integrated Chinese and Western Medicine in Hebei Province were selected and randomized into control group and observation group,with 60 cases in each group.After surgery,the control group was treated with conventional western medicines and the observation group was administered with TJZTP based on the control group's treatment.Both groups were treated continuously for 6 months.The clinical efficacy,TCM pattern scores,serum CA125,tumor necrosis factor-α(TNF-α)levels,and adverse reactions of two groups were compared.Results The total effective rate in the observation group was 96.67%,significantly higher than the control group's 85.00%(P<0.05).After treatment,the TCM pattern scores,the levels of CA125 and TNF-αof the observation group was significantly lower than those of the control group(P<0.01).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion TJZTP can effectively alleviate clinical symptoms of patients with EMS of qi stagnation and blood stasis pattern after laparoscopic surgery,and improve the levels of TNF-αand CA125.

关 键 词：子宫内膜异位症 调经止痛丸 气滞血瘀证 腹腔镜手术 癌胚抗原125 肿瘤坏死因子-α 

分 类 号：R271[医药卫生—中医妇科学]