基于子午流注理论探讨冠心病时间节律机制及中医药干预策略  

Temporal rhythm mechanism of coronary heart disease and the TCM intervention strategies based on the theory of "midnight-noon ebb-flow"

作　　者：陈杏 张书萌 于子璇 朱洁 周江敏 李杰[1] CHEN Xing;ZHANG Shumeng;YU Zixuan;ZHU Jie;ZHOU Jiangmin;LI Jie(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2024年第5期904-911,共8页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(81874375);湖南省自然科学基金项目(2022JJ30430,2023JJ30452);湖南省中医药科研重点课题(C2023002);湖南省教育厅科学研究项目(22A0278,21A0231);湖南中医药大学研究生创新课题(20230795,2022CX06,2022CX57);湖南省普通高等学校科技创新团队支持项目。

摘　　要：冠心病是指冠状动脉粥样硬化导致心肌缺血、缺氧而引起的心脏病,以胸痛、心悸、呼吸困难为主要症状。时间节律是生物体的各种生理机能适应外界环境的昼夜变化而建立起的规律周期,是人类生物钟的重要机制,影响各类疾病。冠心病发病时间节律明显,时间节律振荡机制通过血压、褪黑素、血管内皮炎症因子、时间节律蛋白等来调控冠心病的发展。子午流注理论以中医时间医学理论为基础,以不同时辰经脉气血盛衰,调节人体脏腑气血开阖。子午流注理论干预冠心病发生与现代医学中的时间节律机制有着相似之处,本文主要以子午流注为切入点探究冠心病的时间节律机制,并从子午流注角度综述中医药干预冠心病时间节律的研究进展,为中医药治疗冠心病提供新思路。Coronary heart disease(CHD)refers to a cardiac condition caused by coronary atherosclerosis,leading to myocardial ischemia and hypoxia,with chest pain,palpitations,and dyspnea as the main symptoms.Temporal rhythm is a regular cycle established by various physiological functions of organisms to adapt to the diurnal changes of the external environment,and is an important mechanism of human biological clock and affects various diseases.The onset of CHD has a clear temporal rhythm,the oscillation mechanism of which regulates the development of CHD through blood pressure,melatonin,vascular endothelial inflammatory factors,and temporal rhythm proteins.Based on the TCM chronomedicine,the theory of"midnight-noon ebb-flow"proposes that the opening and closing of qi and blood in the zang-fu organs can be regulated according to the rise and fall of qi and blood in the meridians at different times.The intervention in the occurrence of CHD with the"midnight-noon ebb-flow"theory has similarities with the temporal rhythm mechanism in modern medicine.This paper mainly explores the temporal rhythm mechanism of CHD and reviews the research progress of TCM intervention in the temporal rhythm of CHD from the perspective of "midnight-noon ebb-flow", so as to provide new ideas for the treatment of CHD with TCM.

关 键 词：冠心病 子午流注 时间节律 昼夜节律 血压 褪黑素 中医药 

分 类 号：R256.2[医药卫生—中医内科学]