hs-CRP、hs-cTnⅠ联合BNP检测对急性非ST段抬高型心肌梗死的临床诊断价值  

Clinical Diagnostic Value of hs-CRP,hs-cTnⅠCombined with BNP in Acute Non-ST Elevation Myocardial Infarction

作　　者：黄蓓艳 HUANG Beiyan(Department of Clinical laboratory,Rugao Hospital of Traditional Chinese Medicine,Rugao 226500,Jiangsu,China)

机构地区：[1]如皋市中医院检验科,江苏如皋226500

出　　处：《现代诊断与治疗》2024年第2期165-168,共4页Modern Diagnosis and Treatment

摘　　要：目的探讨血清超敏C-反应蛋白(hs-CRP),超敏肌钙蛋白Ⅰ(hs-cTnⅠ)和B型利钠肽(BNP)水平联合检测对急性非ST段抬高型心肌梗死(NSTEMI)的临床价值。方法选取2021年1月至2023年6月就诊的急性胸痛患者300例,根据诊治结果分为NSTEMI组76例、不稳定性心绞痛组(UA)92例和非急性冠脉综合征组(非ACS)132例,再将NSTEMI组根据HEART评分分为低危亚组、中危亚组和高危亚组,根据入院后72 h的疾病转归情况分为生存亚组和死亡亚组;检测比较各组血清hs-CRP、hs-cTnⅠ和BNP水平,绘制ROC曲线分析hs-CRP、hs-cTnⅠ和BNP水平联合检测对NSTEMI的诊断效能。结果NSTEMI组的hs-CRP、hs-cTnⅠ和BNP水平显著高于UA组和非ACS组,差异有统计学意义(P<0.05)。NSTEMI组中,高危亚组的hs-CRP、hs-cTnⅠ和BNP水平显著高于中危和低危亚组,差异有统计学意义(P<0.05);死亡组的hs-CRP、hs-cTnⅠ和BNP水平显著高于生存组,差异有统计学意义(P<0.05)。ROC曲线显示hs-CRP、hs-cTnⅠ和BNP水平联合检测评估NSTEMI的AUC、敏感度和特异性均显著高于任一单项检测的效能(P<0.01)。结论hs-CRP、hs-cTnⅠ和BNP水平联合检测的效能很高,可为NSTEMI患者的早期诊断、病情监测和预后评估提供科学的参考依据。Objectives To investigate the clinical value of combined detection of serum hypersensitive C-reactive protein(hs-CRP),hypersensitive troponinⅠ(hs-cTnⅠ)and B-type natriuretic peptide(BNP)in patients with acute non-ST-elevation myocardial infarction(NSTEMI).Methods A total of 300 patients with acute chest pain treated in our hospital from January 2021 to June 2023 were selected.According to the diagnosis and treatment results,the patients were divided into NSTEMI group(76cases),unstable angina pectoris(UA)group(92 cases)and non-acute coronary syndrome(non-ACS)group(132case).The NSTEMI group was then divided into low-risk subgroup,medium-risk subgroup and high-risk subgroup according to the HEART score.According to the disease outcomes 72 h after admission,the patients were divided into survival subgroup and death subgroup.The levels of serum hs-CRP,hs-cTnⅠand BNP levels of all groups were detected and compared,and ROC curve was drawn to analyze the diagnostic efficacy of combined detection of hs-CRP,hs-cTnⅠand BNP levels for NSTEMI.Results The levels of hs-CRP,hs-cTnⅠand BNP in NSTEMI group were significantly higher than those in UA group and non-ACS group(P<0.05).In NSTEMI group,the levels of hs-CRP,hs-cTnⅠand BNP inhigh-risk subgroups were significantly higher than those in medium-risk and low-risk subgroups(P<0.05).The levels of hs-CRP,hs-cTnⅠand BNP in the death group were significantly higher than those in the survival group(P<0.05).The ROC curve shows that the AUC,sensitivity and specificity of combined detection of hs-CRP,hs-cTnⅠand BNP levels in evaluating NSTEMI were significantly higher than that of any single detection(P<0.01).Conclusions The combined detection of hs-CRP,hs-cTnⅠand BNP levels is highly effective,which can provide scientific reference for the early diagnosis,disease monitoring and prognosis evaluation of NSTEMI patients.

关 键 词：NSTEMI HS-CRP hs-cTnⅠ BNP 诊断价值 

分 类 号：R446.6[医药卫生—诊断学]