达格列净联合二甲双胍治疗2型糖尿病的效果及安全性分析  

Effectiveness and Safety Analysis of Dapagliflozin Combined with Metfor⁃min in the Treatment of Type 2 Diabetes Mellitus

作　　者：王丽 李振 张双 WANG Li;LI Zhen;ZHANG Shuang(Department of Pharmacy,Jinan Jiyang District Hospital of Traditional Chinese Medicine,Jinan,Shandong Province,251400 China;Department of Pharmacy,Jinan Tianqiao People's Hospital,Jinan,Shandong Province,250031 China)

机构地区：[1]济南市济阳区中医医院药剂科,山东济南251400 [2]济南市天桥人民医院药剂科,山东济南250031

出　　处：《糖尿病新世界》2024年第5期87-90,共4页Diabetes New World Magazine

摘　　要：目的探讨达格列净、二甲双胍共同应用在2型糖尿病(Type 2 Diabetes Mellitus,T2DM)临床治疗中的疗效和安全性。方法选取济南市济阳区中医医院于2021年10月—2023年10月收治的94例T2DM患者为研究对象,随机数表法分为观察组及对照组,各47例。对照组单独使用二甲双胍治疗,研究组使用达格列净与二甲双胍联合治疗,比较两组治疗效果及安全性。结果治疗后,研究组患者空腹血糖、餐后2 h血糖、糖化血红蛋白水平低于对照组,差异有统计学意义(P均<0.05)。研究组患者三酰甘油、低密度脂蛋白胆固醇、总胆固醇水平低于对照组,差异有统计学意义(P均<0.05)。研究组患者生活质量各项评分优于对照组,差异有统计学意义(P<0.05)。两组患者不良反应总发生率对比,差异无统计学意义(P>0.05)。结论在2型糖尿病患者的临床治疗过程中达格列净、二甲双胍共同应用具有更加明显的疗效,可改善患者的血糖和血脂指标水平,提升患者生活的质量,且具有较高的安全性。Objective To investigate the efficacy and safety of dapagliflozin and metformin in the clinical treatment of type 2 diabetes mellitus(T2DM).Methods A total of 94 patients with T2DM admitted to Jinan Jiyang District Hospi-tal of Traditional Chinese Medicine from October 2021 to October 2023 were selected as the study objects and were randomly divided into a study group and a control group by random number table method;with 47 cases in each group.The control group was treated with metformin alone,and the study group was treated with dapagliflozin and met-formin.The therapeutic effect and safety of the two groups were compared.Results After treatment,the levels of fast-ing plasma glucose,2-hour postprandial blood glucose,glycosylated hemoglobin A1c in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of triglycer-ide,low-density lipoprotein cholesterol,and total cholesterol in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The scores of quality of life in the study group were better than those in the control group,and the differences were statistically significant(P<0.05).The total inci-dence of adverse reactions between the two groups has no statistically significant difference(P>0.05).Conclusion In the clinical treatment of type 2 diabetes mellitus,the combined application of dapagliflozin and metformin has more obvious efficacy,which can improve the level of blood glucose and lipid indexes of patients and enhance the quality of life of patients,with a high degree of safety.

关 键 词：达格列净 二甲双胍 2型糖尿病 临床疗效 安全性 

分 类 号：R9[医药卫生—药学]