达格列净联合甘精胰岛素在老年T2DM患者糖代谢控制中的应用效果  

The Application Effect of Dapagliflozin Combined with Glargine Insulin in Carbohydrate Metabolism Control of Elderly T2DM Patients

作　　者：谢立凯[1] 孙亚东[1] XIE Likai;SUN Yadong(Department of Endocrine and Metabolic DiseasesⅠ,Jilin Provincial People's Hospital,Changchun,Jilin Province,)

机构地区：[1]吉林省人民医院内分泌代谢病一科,吉林长春130012

出　　处：《糖尿病新世界》2024年第5期95-98,共4页Diabetes New World Magazine

摘　　要：目的分析老年2型糖尿病(Type 2 Diabetes Mellitu,T2DM)患者糖代谢控制中达格列净与甘精胰岛素联合应用的效果。方法选取2021年5月—2023年5月吉林省人民医院收治的100例老年T2DM患者为研究对象,以信封法分为观察组(n=50,行达格列净联合甘精胰岛素治疗)、比照组(n=50,行单纯甘精胰岛素治疗)。观察并对比两组患者临床疗效、糖代谢控制情况及不良反应总发生率。结果治疗3个月后,两组糖代谢水平均明显低于治疗前,且观察组空腹血糖(6.01±0.28)mmol/L、餐后2 h血糖(7.41±1.18)mmol/L、糖化血红蛋白(6.58±1.04)%均低于比照组,差异有统计学意义(t=2.171、2.595、2.077,P均<0.05)。观察组临床总有效率(96.00%)高于比照组,差异有统计学意义(χ^(2)=5.005,P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论老年T2DM患者糖代谢控制中,达格列净联合甘精胰岛素的应用效果显著,糖代谢水平得到明显改善的同时,临床疗效更加显著,不良反应发生风险未产生明显升高情况,说明上述两种药物联合应用,具有较高的安全性。Objective To analyze the effect of dapagliflozin combined with glargine insulin on carbohydrate metabo-lism control in elderly patients with type 2 diabetes mellitus(T2DM).Methods 100 elderly T2DM patients admitted to Jilin Provincial People's Hospital from May 2021 to May 2023 were selected as the study objects.They were divided into observation group(n=50,treated with dapagliflozin combined with glargine insulin)and comparison group(n=50,treated with simple glargine insulin)using the envelope method.The clinical efficacy,carbohydrate metabolism con-trol,and total incidence of adverse reactions between two groups of patients were observed and compared.Results Af-ter 3 months of treatment,the carbohydrate metabolism level in two groups was significantly lower than before treat-ment,and the fasting blood glucose(6.01±0.28)mmol/L,2-hour postprandial blood glucose(7.41±1.18)mmol/L,and glycated hemoglobin(6.58±1.04)%in the observation group were lower than those in the comparison group,and the differences were statistically significant(t=2.171,2.595,2.077,all P<0.05).The total clinical effective rate of the ob-servation group(96.00%)was higher than that of the comparison group,and the difference was statistically significant(χ^(2)=5.005,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions be-tween the two groups(P>0.05).Conclusion In the control of carbohydrate metabolism of elderly T2DM patients,the application of dapagliflozin and glargine insulin was effective,and while the level of carbohydrate metabolism was sig-nificantly improved,the clinical efficacy was more significant,and the risk of adverse reactions did not produce a sig-nificant elevation of the situation,indicating that the combined application of the above two drugs has a high degree of safety.

关 键 词：老年T2DM患者 达格列净 甘精胰岛素 糖代谢 临床疗效 不良反应 

分 类 号：R587.1[医药卫生—内分泌]