肠道菌群失衡与糖尿病肾病的关系及中药防治研究进展  

Research progress of the relationship between intestinal flora imbalance and diabetic nephropathy and its prevention and treatment by traditional Chinese medicine

作　　者：魏金凤 魏晓涛 张新丽[3] 王威威 WEI Jinfeng;WEI Xiaotao;ZHANG Xinli;WANG Weiwei(Special Needs Ward,Jiu Gang Hospital,Jiayuguan 735100,Gansu Province,China;Clinical School of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Nephrology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]酒钢医院特需病区,甘肃嘉峪关735100 [2]甘肃中医药大学中医临床学院,兰州730000 [3]甘肃省中医院肾病科,兰州730000

出　　处：《数理医药学杂志》2024年第5期371-377,共7页Journal of Mathematical Medicine

基　　金：甘肃省中医药管理局重点课题(GZKG-2022-3)。

摘　　要：肠道菌群作为人体最大的微生物库,种类丰富,与健康和疾病的发生发展密切相关。肠道菌群失衡已被证实与糖尿病肾病(diabetic nephropathy,DN)发病存在相关性,肠道内条件致病菌种类及数量越多,DN患者肾脏损害越严重。干预肠道菌群结构,增加有益菌群丰度,可有效改善肾脏功能和肾脏病理损害,防治DN,改善终末期肾脏疾病预后不良。中医药治疗DN具有低价效优、不良反应小、靶点多、途径广等优点,在防治DN中占据重要地位,且可与西药联合使用,达到取长补短、标本兼治的优势。中医药通过干预肠道菌群治疗DN疗效显著,但中医外治法对于DN的研究相对有限。本文针对肠道菌群与DN的关系及中药活性成分、中药复方及中药灌肠干预肠道菌群的研究进展进行综述,以期为中医药防治DN提供参考。As the largest microbial pool in human body,intestinal flora is rich in species,which is closely related to the development of health and disease.The imbalance of intestinal flora has been confirmed to be related to the pathogenesis of diabetic nephropathy(DN),and the more types and quantities of intestinal conditional pathogenic bacterium,the more serious renal damage in DN patients.Intervening the structure of intestinal flora and increasing the abundance of beneficial bacteria can effectively improve renal function and renal pathological damage,prevent DN and improve the poor prognosis of end-stage renal disease.Traditional Chinese medicine in the treatment of DN has the advantages of low price,good effect,small adverse reactions,more targets and wide channels.It occupies an important position in the prevention and treatment of DN,and can combine with western medicine to achieve the advantages of learning from each other and treating both symptoms and root causes.Traditional Chinese medicine has remarkable therapeutic effect on DN by interfering with intestinal flora,but the research on external treatment of traditional Chinese medicine is relatively limited.This paper reviewed the research progress of the relationship between intestinal flora and DN,and the active ingredients of traditional Chinese medicine,traditional Chinese medicine compound and enema intervention of traditional Chinese medicine on intestinal flora,in order to provide reference for the prevention and treatment of DN by traditional Chinese medicine.

关 键 词：糖尿病肾病 肠道菌群 慢性肾脏病 中药 

分 类 号：R277.5[医药卫生—中医学] R259