针刺治疗骨转移癌痛的临床及机制研究进展  

Progress of clinical and mechanistic studies on acupuncture in the treatment of cancer induced bone pain

作　　者：徐文清 曾晓铃 徐世芬[1] 殷萱 XU Wen-qing;ZENG Xiao-ling;XU Shi-fen;YIN Xuan(Department of Acupuncture and Moxibustion,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院针灸科,上海200071

出　　处：《中国疼痛医学杂志》2024年第5期363-370,共8页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金(82104986);上海市科委扬帆计划(20YF1446200);上海市科委医学创研究专项(20Y21903000)。

摘　　要：骨转移癌痛是中重度癌症疼痛最常见的类型,其发病机制复杂,目前机制研究多集中在兴奋脊髓神经元、激活胶质细胞、不同受体的活化等方面。目前治疗药物存在一定的不良反应。临床研究表明针刺治疗骨转移癌痛可以减轻药物耐受和不良反应、增进疗效,减少镇痛药物的剂量,同时改善病人的焦虑、抑郁症状,提高生存质量。针刺可能通过调节神经递质释放、抑制胶质细胞活化以及调节下行抑制和易化系统等途径发挥镇痛效应。本文就骨转移癌痛的发病机制及针刺治疗骨癌痛的临床及基础研究进行综述,以期进一步为针刺镇痛的机制研究及临床应用提供科学依据。Cancer induced bone pain(CIBP)is the most common kind of moderate and severe cancer pain,and its pathogenesis is complicated.Mechanistic studies have focused on spinal neuron activation,glial cell activation,activation of different receptors and so on.Modern medicine have some toxic side events.Clinical studies have shown that acupuncture can reduce drug tolerance and side effects,reduce the dosage of analgesics,improve anxiety and depression,and thus improve the patients'quality of life.Its mechanisms include regulating the release of neurotransmitters,inhibiting glial cell activation and regulating descending inhibition and facilitation system.This paper reviewed the researches on the pathogenesis of CIBP,as well as the clinical and basic studies on the acupuncture treatment for CIBP,hoping to provide further evidence on the clinical application and mechanism researches on acupuncture in relieving pain.

关 键 词：骨转移癌痛 针刺 镇痛 研究进展 

分 类 号：R246.5[医药卫生—针灸推拿学]