长期模拟失重实验中医证候诊断量表的研究  

Development of a Traditional Chinese Medicine syndrome diagnosis scale for long-term simulated weightlessness experiments

作　　者：石宏志[1] 徐冲[1] 许家佗[2] 范全春[1] 刘军莲[1] 屠立平[2] 胡晓娟[2] 张成普 赵爽[1] 米涛[1] 李勇枝[1] 李莹辉[1] Shi Hongzhi;Xu Chong;Xu Jiatuo;Fan Quanchun;Liu Junlian;Tu Liping;Hu Xiaojuan;Zhang Chengpu;Zhao Shuang;Mi Tao;Li Yongzhi;Li Yinghui(National Key Laboratory of Space Medicine,China Astronaut Research and Training Center,Beijing 100094,China;School of Basic Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]中国航天员科研训练中心航天医学全国重点实验室,北京100094 [2]上海中医药大学基础医学院,上海201203

出　　处：《航天医学与医学工程》2024年第1期8-14,共7页Space Medicine & Medical Engineering

基　　金：载人航天工程航天医学实验领域项目资助(HYZHXM05001)。

摘　　要：目的制订适用于长期模拟失重实验受试者整体健康状态评价的中医证候诊断量表,并对其信度与效度进行初步评价。方法本研究基于对长期航天飞行不同阶段中的人体中医病机的认识,通过文献调研结合专家咨询的方法制订量表。采用重测信度和内部一致性系数来检验量表信度;进行为期90 d的头低位卧床实验,采用项目分析和因子分析法评价量表的效度,采用旋转成分矩阵分析各条目与维度间的相关性。结果长期模拟失重实验中医证候诊断量表包含8个维度、57个条目。信度分析结果:30名受试者前后两次量表评分总分相关系数为0.889,表明量表的稳定性很高;量表的克龙巴赫α系数为0.934,表明量表内部一致性非常好;分半信度校正后为0.858,表明量表的信度很高。效度分析结果:57个条目在高分组和低分组的差异均有统计学意义(P<0.01),各条目与量表总分的皮尔逊相关系数均>0.4(P<0.001);采用主成分因子分析法提取8个公因子,累积贡献率为55.293%;旋转成分矩阵分析结果经医理分析和专家反馈显示,与初始8个维度的重合度高达87.5%,表明量表的结构效度良好。结论量表具有良好的信度和效度,能够进行中医证候诊断,适用于长期模拟失重实验,可为受试者主观感受的评价提供客观量化新方法。Objective To develop a Traditional Chinese Medicine(TCM)syndrome diagnosis scale suitable for evaluating the overall health status of participants in long-term simulated weightlessness experiments,and preliminarily evaluate its reliability and validity.Methods Based on the understanding of the pathogenesis of TCM in different stages of long-term manned spaceflight,a scale was developed through literature research and expert consultation.Test-retest reliability and internal consistency coefficient were used to test the reliability of the scale.Item analysis and factor principal component analysis were used to evaluate the validity of the scale,and a rotating component matrix was used to analyze the correlation between each item and dimension using 36 volunteers in a 90 days head down bed rest experiment as the research subjects.Results The scale contains eight dimensions and 57 items.The reliability analysis showed that the correlation coefficient of the total score of the scale for the first and second tests of 30 participants was 0.889,indicating high stability of the scale.The Cronbach coefficient of the scale was 0.934,indicating very good internal consistency.The split half reliability after correction was 0.858,indicating a high reliability of the scale.The validity analysis showed that the difference between the high score group and the low score one for each of the 57 items was statistically significant(P<0.01),and the Pearson correlation coefficient between each item and the total score of the scale was greater than 0.4(P<0.001).The cumulative contribution rate of 8 common factors extracted using principal component factor analysis was 55.293%,and the results of rotating component matrix analysis,after applying TCM theory and expert feedback,had a coincidence of up to 87.5%with the initial 8 dimensions,indicating good structural validity of the scale.Conclusion The scale has good reliability and validity,and can diagnose TCM syndromes.It is suitable for long-term simulated weightlessness experiment and pr

关 键 词：长期模拟失重实验 中医 证候 诊断 量表 

分 类 号：R852.2[医药卫生—航空、航天与航海医学]