缺血性神经阻滞状态下神经肌肉电刺激诱发感觉皮层活动的研究  

NMES-evoked somatosensory cortical response under ischemic nerve block

作　　者：赵云 谢光辉[1] 闫艳影 秦海燕 高凤梅[1] 杨仁强 孙红[1] 古绍洁 蒋勤 吴小鹰[2,3] 侯文生 Zhao Yun;Xie Guanghui;Yan Yanying;Qin Haiyan;Gao Fengmei;Yang Renqiang;Sun Hong;Gu Shaojie;Jiang Qin;Wu Xiaoying;Hou Wensheng(Chongqing College of Electronic Engineering,School of Smart Health,Chongqing 401331,China;the Key Laboratory of Biorheological Science and Technology of Ministry of Education,Chongqing University,Chongqing 400044,China;Chongqing Medical Electronics Engineering Technology Research Center,Chongqing 400044,China)

机构地区：[1]重庆电子工程职业学院智慧健康学院,重庆401331 [2]重庆大学生物流变科学与技术教育部重点实验室,重庆400044 [3]重庆市医疗电子工程技术研究中心,重庆400044

出　　处：《航天医学与医学工程》2024年第1期42-46,共5页Space Medicine & Medical Engineering

基　　金：重庆市教育委员会科学技术研究项目重点项目(KJZD-K202303103,KJZD-K202203104);重庆市教育委员会科学技术研究项目青年项目(KJQN202303123)。

摘　　要：目的基于缺血性神经阻滞(INB)技术能够成功剥离出运动阈值上神经肌肉电刺激(NMES)前臂肌肉诱发的肌梭感觉传入信息,本文旨在探究INB状态下感觉运动皮层如何感知运动阈值上NMES所诱发的肌梭感觉传入信息。方法本文设计了一个2×2因素(INB:前、后;NMES强度:运动阈值上、下)的实验任务方案,任务期间记录健康受试者大脑64通道脑电信号,并利用脑电beta频段的事件相关去同步化(beta ERD)量化感觉运动皮层区域的激活水平。通过心理物理学测试评估血压袖带施加于右手腕处后受试者右手感觉与运动的变化。结果在INB状态下,运动阈值上NMES诱发的对侧感觉运动皮层脑电beta ERD显著减弱,并且在INB施加前,运动阈值上、下NMES诱发的对侧感觉运动皮层脑电beta ERD幅值差异具有统计学意义(P<0.05),但是此差异在INB状态下消失。此外,阻滞成功后NMES诱发的感觉运动皮层脑电beta ERD的对侧优势转移到了同侧。结论INB导致运动阈值上NMES诱发的皮层活动显著减弱,对侧感觉运动皮层对NMES刺激强度的感知减弱,这可能由INB引起感觉运动皮层产生快速功能重塑造成。Objective Neuromuscular electrical stimulation(NMES)-evoked kinesthetic information in muscle spindle can be purely extracted from the mixed motor and sensory afferents using Ischemic nerve block(INB).This study aims to investigate the somatosensory cortical response evoked by NMES activating muscle spindle afferents in forearm.Methods All subjects performed four experimental tasks designed according to a 2×2 factors,including one factor of the INB state(without INB and within INB)and the other of the stimulation intensity(above and below motor threshold).During the experiment,we recorded EEG data with 64 channels and then beta eventrelated desynchronization(Beta ERD)were utilized quantize somatosensory cortical excitability evoked by the tasks.The subjective perception about the sensation and movement of the right hand were evaluated by a psychophysical test after the right wrist was performed by INB.Results INB significantly reduced beta ERD on the contralateral somatosensory cortex evoked by NMES above the motor threshold,and there was significant difference of NMESevoked beta ERD values on the contralateral somatosensory cortex between above and below motor threshold.Meanwhile,contralateral dominance of NMES-evoked beta ERD on the somatosensory cortex was transferred to ipsilateral hemisphere under INB.Conclusion INB can significantly reduce NMES-evoked somatosensory cortical response above motor threshold and decrease cortical perception on the stimulus intensity,which may be due to INB resulting in rapid functional reorganization of somatosensory cortex.

关 键 词：缺血性神经阻滞 神经肌肉电刺激 肌梭 躯体感觉皮层 

分 类 号：R338[医药卫生—人体生理学]