维生素D_(3)对多囊卵巢综合征孕妇血脂代谢和妊娠并发症的影响  

Influence of vitamin D_(3) on lipid metabolism and pregnancy complications in pregnant women with polycystic ovary syndrome

作　　者：葛榕[1] 陈品玲[1] 郑琳 林靓[1] 辛长征 李蕊[1] Ge Rong;Chen Pinling;Zheng Lin;Lin Liang;Xin Changzheng;Li Rui(Shengli Clinical Medical College of Fujian Medical University,Fuzhou 350001,Fujian,China)

机构地区：[1]福建医科大学省立临床医学院,福建福州350001

出　　处：《创伤与急诊电子杂志》2024年第1期60-65,共6页Journal of Trauma and Emergency(Electronic Version)

基　　金：福建省自然科学基金资助项目(2020J011102)。

摘　　要：目的观察补充维生素D_(3)对多囊卵巢综合征孕妇的血脂代谢和妊娠并发症的影响。方法选取福建省立医院2021年1月2022年12月就诊的多囊卵巢综合征孕妇50例作为观察组,自妊娠12周前开始,每日口服400单位维生素D_(3)滴剂。采用1∶1配对,配对因素为年龄、孕次、产次和体重指数,选取同期于福建省立医院分娩,且妊娠期间未服用维生素D_(3)的多囊卵巢综合征孕妇50例作为对照组。比较两组孕妇基线及孕37周的外周血25-羟基维生素D水平、血脂代谢指标,以及妊娠并发症情况。结果孕37周时,与对照组相比,观察组的外周血25-羟基维生素D水平明显升高[(34.55±5.71)ng/ml比(19.12±4.57)ng/ml,t=15.497,P<0.001],而甘油三酯[(1.50±0.37)mmol/L比(1.66±0.42)mmol/L]、总胆固醇[(4.66±0.62)mmol/L比(4.99±0.83)mmol/L]和低密度脂蛋白[(2.69±0.47)mmol/L比(2.87±0.61)mmol/L]水平均较对照组明显降低(P均<0.05)。相关性分析结果显示,观察组孕妇妊娠37周时的外周血25-羟基维生素D水平与甘油三酯(r=﹣0.612,P<0.001)、总胆固醇(r=﹣0.670,P<0.001)和低密度脂蛋白(r=﹣0.688,P<0.001)水平呈负相关,与高密度脂蛋白水平呈正相关(r=0.652,P<0.001)。观察组患者的妊娠并发症总发生率明显低于对照组(64.00%比92.00%,χ^(2)=11.422,P=0.001)。结论多囊卵巢综合征孕妇补充维生素D_(3),有利于纠正患者自身的血脂代谢紊乱,减少妊娠并发症,改善分娩结局。Objective To observe the influence of vitamin D3 supplementation on lipid metabolism and pregnancy outcomes in pregnant women with polycystic ovary syndrome.Method From January 2021 to December 2022,50 pregnant women with polycystic ovary syndrome were selected for the observational study and received 400 units of vitamin D3 drops orally every day from 12 weeks of gestation.Another 50 paired pregnant women with polycystic ovary syndrome who gave birth at the same time without taking vitamin D3 were served as the control group.The serum 25-hydroxyvitamin D level and the lipid metabolism parameters at the 37th week of gestation,as well as the pregnancy complications were compared between the two groups.Result Compared with the control group,the serum 25-hydroxyvitamin D level in the observational group was significantly increased[(34.55±5.71)ng/ml vs(19.12±4.57)ng/ml,t=15.497,P<0.001],while the levels of serum triglyceride[(1.50±0.37)mmol/L vs(1.66±0.42)mmol/L],total cholesterol[(4.66±0.62)mmol/L vs(4.99±0.83)mmol/L]and low-density lipoprotein[(2.69±0.47)mmol/L vs(2.87±0.61)mmol/L]in the observational group were significantly lower than those in the control group(all P<0.05).The results of correlation analysis showed that the level of serum 25-hydroxyvitamin D at the 37th week of gestation in the observation group was negatively correlated with triglyceride(r=﹣0.612,P<0.001),total cholesterol(r=﹣0.670,P<0.001)and low-density lipoprotein(r=﹣0.688,P<0.001),but positively correlated with high-density lipoprotein(r=0.652,P<0.001).The incidence of pregnancy complications in the observation group was significantly lower than that in the control group(64.00%vs 92.00%,χ^(2)=11.422,P=0.001).Conclusion Vitamin D3 supplementation in pregnant women with polycystic ovary syndrome is beneficial to correcting the disorders of lipid metabolism,reducing pregnancy complications and improving the outcome of pregnancy.

关 键 词：多囊卵巢综合征 维生素D_(3) 血脂 妊娠并发症 

分 类 号：R711.75[医药卫生—妇产科学]