二氧化碳点阵激光结合倍他米松局部注射治疗非节段型白癜风的效果  

Effect of Carbon Dioxide Dot Matrix Laser Combined with Betamethasone Local Injection in the Treatment of Non-segental Vitiligo

作　　者：陈琼 王萍 高亚丽 程灵云 CHEN Qiong;WANG Ping;GAO Yali;CHENG Lingyun(Department of Dermatology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属郑州中心医院皮肤科,河南郑州450000

出　　处：《河南医学研究》2024年第10期1769-1772,共4页Henan Medical Research

摘　　要：目的 研究二氧化碳(CO_(2))点阵激光结合倍他米松局部注射治疗非节段型白癜风的效果及对外周血白细胞介素-33(IL-33)、可溶性致癌抑制因子2(sST2)表达的影响。方法 选取2022年1月至2023年1月郑州大学附属郑州中心医院收治的78例非节段型白癜风患者,依据随机数字表法分为对照组、观察组,各39例。对照组接受倍他米松局部注射治疗,观察组接受CO_(2)点阵激光结合倍他米松局部注射治疗。比较两组临床疗效及治疗前、治疗3个月后皮损分布评分、皮损面积与严重指数(PASI)评分、皮肤病生活质量指数量表(DLQI)评分、血清免疫球蛋白水平(IgA、IgG、IgM)、外周血白细胞介素-17(IL-17)、IL-33、sST2、细胞间黏附分子-1(ICAM-1)水平、不良反应发生率。结果 观察组临床总有效率高于对照组(P<0.05);治疗3个月后,观察组皮损分布、PASI、DLQI评分,血清IgA、IgG、IgM水平及外周血IL-17、IL-33、sST2、ICAM-1水平低于对照组(P<0.05);两组间不良反应总发生率差异无统计学意义(P>0.05)。结论 采用CO_(2)点阵激光与倍他米松局部注射联合治疗非节段型白癜风患者能提高效果,降低炎症程度,促进免疫功能恢复,改善皮损状态。Objective To study the effect of carbon dioxide(CO_(2))dot matrix laser combined with betamethasone local injection in the treatment of non-segment vitiligo and the expression of interleukin-33(IL-33)and soluble suppression of tumorigenicity 2(sST2)in peripheral blood.Methods Seventy-eight patients with non-segmental vitiligo treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2022 to January 2023 were selected as the research objects,and were divided into control group and observation group by random number table method,with 39 cases in each group.The control group was treated with local injection of betamethasone,and the observation group was treated with CO_(2) dot matrix laser combined with local injection of betamethasone.The clinical efficacy,lesion distribution score,psoriasis area and severity index(PASI)score,dermatological quality of life index(DLQI)score,serum immunoglobulin levels(IGA,IgG,IgM),peripheral blood interleukin-17(IL-17),IL-33,sST2,intercellular adhesion molecule-1(ICAM-1)levels and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(89.74%)was higher than that of the control group(71.79%)(P<0.05).After 3 months of treatment,the lesion distribution,PASI and DLQI scores,the levels of serum IgA,IgG and IgM and IL-17,IL-33,sST2 and ICAM-1 in the observation group were lower than those in the control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the observation group(28.21%)and the control group(17.95%)(P>0.05).Conclusion The combination of CO_(2) dot matrix laser and betamethasone injection can significantly improve the curative effect,reduce the degree of inflammation,promote the recovery of immune function and improve the state of skin lesions.

关 键 词：二氧化碳点阵激光 倍他米松 非节段型白癜风 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]