乳酸脱氢酶/白蛋白对多发性骨髓瘤患者硼替佐米化疗耐药的影响  

Effect of Lactate Dehydrogenase/Albumin on Bortezomib Chemoresistance in Patients with Multiple Myeloma

作　　者：田颖[1] 王根杰[1] 胡青竹[1] TIAN Ying;WANG Genjie;HU Qingzhu(Department of Hematology,the First People’s Hospital of Shangqiu,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院血液内科,河南商丘476100

出　　处：《河南医学研究》2024年第10期1806-1809,共4页Henan Medical Research

摘　　要：目的 探讨乳酸脱氢酶(LDH)/白蛋白(ALB)对多发性骨髓瘤(MM)患者硼替佐米化疗耐药的影响。方法 回顾性分析商丘市第一人民医院2021年5月至2023年5月收治的124例MM患者的临床资料。所有患者均已接受4个周期的硼替佐米联合地塞米松化疗。依据MM疗效评价标准评定化疗耐药情况,将发生耐药患者资料纳入发生组(16例),未发生耐药患者资料纳入未发生组(108例)。比较两组性别、Durie-Salmon分期、MM病程等一般资料;比较化疗前测得的LDH、ALB及其他实验室指标,并计算LDH/ALB值。通过受试者工作特征(ROC)曲线和点二列相关性分析探讨LDH/ALB对MM患者硼替佐米化疗耐药的影响。结果 发生组Ⅲ期占比、LDH、LDH/ALB高于未发生组,ALB低于未发生组,差异有统计学意义(P<0.05)。经点二列相关性分析显示,LDH/ALB、LDH、ALB与MM患者硼替佐米化疗耐药发生有关(P<0.05)。绘制ROC曲线,结果显示,LDH、ALB、LDH/ALB预测MM患者硼替佐米化疗耐药发生的曲线下面积值分别为0.791、0.780、0.849,LDH/ALB预测价值最高。结论 LDH/ALB可对MM患者硼替佐米化疗耐药产生影响,其值越高,化疗耐药发生率越高。Objective To investigate the effect of lactate dehydrogenase(LDH)/albumin(ALB)on bortezomib chemoresistance in patients with multiple myeloma(MM).Methods The clinical data of 124 MM patients admitted to the First People’s Hospital of Shangqiu from May 2021 to May 2023 were retrospectively analyzed.All patients have received 4 cycles of bortezomib plus dexamethasone chemotherapy.According to the MM efficacy evaluation criteria,the chemotherapy resistance was evaluated.The data of patients with drug resistance were included in the occurrence group(16 cases),and the data of patients without drug resistance were included in the non occurrence group(108 cases).General data such as gender,Durie-Salmon stage,and MM course were compared between the two groups.LDH,ALB and other laboratory indexes were compared before chemotherapy,and LDH/ALB value was calculated.The effect of LDH/ALB on bortezomib chemoresistance in MM patients was investigated by receiver operating characteristic(ROC)curve and point binary correlation analysis.Results The proportion of stageⅢ,LDH,LDH/ALB in the occurrence group were higher than those in the non occurrence group,and ALB was lower than those in the non occurrence group,with a statistical significant difference(P<0.05).The point binary correlation analysis showed that LDH/ALB,LDH,ALB were related to the occurrence of bortezomib resistance in MM patients(P<0.05).The ROC was drawn,and the results showed that the area under the curve values of LDH,ALB,LDH/ALB to predict the occurrence of bortezomib chemotherapy resistance in MM patients were 0.791,0.780,0.849,respectively.LDH/ALB had the highest predictive value.Conclusion LDH/ALB can affect the chemoresistance of MM patients to bortezomib.The higher the value,the higher the probability of chemoresistance.

关 键 词：多发性骨髓瘤 乳酸脱氢酶 白蛋白 硼替佐米 

分 类 号：R551.3[医药卫生—血液循环系统疾病]