百令片联合司美格鲁肽治疗糖尿病肾病的效果  

Effect of Baling Tablet Combined with Semaglutide in the Treatment of Diabetic Nephropathy

作　　者：陈雪辉[1] 尹清风[1] 孟祥雨 耿锐娜 朱铁锤[2] 徐云 白立炜[1] CHEN Xuehui;YIN Qingfeng;MENG Xiangyu;GENG Ruina;ZHU Tiechui;XU Yun;BAI Liwei(Ward 1,Department of Endocrinology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China;Department of Nephrology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院内分泌科一病区,河南新乡453100 [2]新乡医学院第一附属医院肾病科二病区,河南新乡453100

出　　处：《河南医学研究》2024年第10期1853-1856,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190458)。

摘　　要：目的 探讨百令片联合司美格鲁肽治疗糖尿病肾病(DN)的效果。方法 本研究为前瞻性研究,研究对象选自新乡医学院第一附属医院2021年9月至2023年6月收治的DN患者,共150例,以随机数字表法将其分为对照组(75例)、研究组(75例)。两组均接受基础治疗,对照组在此基础上接受司美格鲁肽治疗,研究组在对照组基础上接受百令片治疗。治疗6个月,比较两组疗效、治疗前后空腹血糖(FBG)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、糖化血红蛋白(HbA1c)、半胱天冬氨酸酶(Caspase-1)、胱抑素C(Cys-C)、餐后2 h血糖(2 h PG)、血肌酐(Scr)、白介素-1β(IL-1β)、IL-18、β_(2)微球蛋白(β_(2)-MG)、超氧化物歧化酶(SOD)、丙二醛(MDA)、血尿素氮(BUN)、总抗氧化能力(T-AOC)及不良反应。结果 研究组总有效率高于对照组(P<0.05),治疗6个月后,研究组FBG、2 h PG、HbA1c、NLRP3、Caspase-1、IL-1β、IL-18、Scr、BUN、Cys-C、β_(2)-MG水平较对照组低(P<0.05);治疗6个月后,研究组T-AOC、SOD水平较对照组高,MDA水平较对照组低(P<0.05);研究组不良反应总发生率与对照组比较,差异无统计学意义(P>0.05)。结论 司美格鲁肽与百令片联合治疗DN患者的效果良好,可有效调控NLRP3炎症小体相关因子,减轻氧化应激,增强降糖效果,从而改善肾功能,且无明显不良反应。Objective To investigate the effect of Bailing tablet combined with Semaglutide on diabetic nephropathy(DN).Methods This study is a prospective study,and the subjects were selected from 150 DN patients admitted to the First Affiliated Hospital of Xinxiang Medical University from September 2021 to June 2023.They were randomly divided into a reference group(75 cases)and a study group(75 cases)using a random number table method.Both groups received basic treatment,and the reference group received treatment with semaglutide on top of this.The study group received treatment with Bailing tablets on top of the reference group.After 6 months of treatment,the efficacy,fasting blood glucose(FBG),nucleotide binding oligomerization domain-like receptor protein 3(NLRP3),glycosylated hemoglobin(HbA1c),cysteine asparaginase(Caspase-1),cystatin C(Cys-C),2 h postprandial glucose(2 h PG),blood creatinine(Scr),interleukin-1β(IL-1β),IL-18,β_(2) microglobulin(β_(2)-MG),superoxide dismutase(SOD),malondialdehyde(MDA),blood urea nitrogen(BUN),total antioxidant capacity(T-AOC)and adverse reactions were compared.Results The total effective rate of the study group was higher than that of the reference group(P<0.05).After 6 months of treatment,the levels of FBG,2 h PG,HbA1c,NLRP3,Caspase-1,IL-1β,IL-18,Scr,BUN,Cys-C,andβ_(2)-MG in the study group were lower than those in the reference group(P<0.05).After 6 months of treatment,the levels of T-AOC and SOD in the study group were higher than those in the reference group,while the level of MDA was lower than that in the reference group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the study group and the reference group(P>0.05).Conclusion The combination of semiglutide and Baling tablet has good efficacy in the treatment of DN patients,which can effectively regulate NLRP3 inflammator-related factors,reduce oxidative stress,enhance hypoglycemic effect,and thus improve renal function without obvious adverse reactions.

关 键 词：百令片 司美格鲁肽 糖尿病肾病 NLRP3 肾功能 血糖 炎症 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]