加味桂枝茯苓丸治疗痰瘀互结型多囊卵巢综合征患者的效果  

Effect of Modified Guizhi Fuling Pills on Patients with Polycystic Ovary Syndrome

作　　者：李彦茹 李会娟[1] 徐广立 田超 方蕾 郭婧[1] 景竹青 王晶[1] LI Yanru;LI Huijuan;XU Guangli;TIAN Chao;FANG Lei;GUO Jing;JING Zhuqing;WANG Jing(Department of Reproductive Medicine District 2,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院生殖医学科二区,河南郑州450000

出　　处：《河南医学研究》2024年第10期1869-1873,共5页Henan Medical Research

基　　金：河南省二○二三年度科技发展计划项目(232102310246)。

摘　　要：目的 探讨加味桂枝茯苓丸治疗痰瘀互结型多囊卵巢综合征(PCOS)患者的效果。方法 将2020年9月至2022年12月于河南中医药大学第一附属医院就诊的115例痰瘀互结型PCOS患者纳入研究,经过筛查以后最后纳入106例,根据随机数字表法将其分为中药组(在基础组的治疗上加用桂枝茯苓丸治疗,53例)和基础组(炔雌醇环丙孕酮片、来曲唑片治疗,53例)。对所有患者一般临床资料和内分泌代谢特征进行分析,并观察两组临床疗效、激素水平变化、月经改善情况和体外受精-胚胎移植(IVF-ET)妊娠结局。结果 两组年龄、体重指数(BMI)、腰臀比(WHR)、Ferriman-Gallway(F-G)评分、痤疮综合分级系统(GAGS)评分、左右卵巢体积比较,差异无统计学意义(P>0.05)。中药组治疗总有效率高于基础组(P<0.05)。中药组治疗后血清卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))、睾酮(T)水平改善均优于基础组;中药组月经各项改善情况均优于基础组,差异有统计学意义(P<0.05);中药组获卵数、成胚数受精率、优胚率和临床妊娠率高于基础组,差异有统计学意义(P<0.05)。结论 加用加味桂枝茯苓丸治疗痰瘀互结型PCOS患者,其临床疗效要优于常规治疗,能有效调整LH、T激素水平,改善月经情况和生殖功能,提高受精率、优胚率和妊娠率,值得临床推广。Objective To explore the effect of modified Guizhi Fuling pills in patients with polycystic ovary syndrome(PCOS).Methods A total of 115 patients with PCOS attending the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from September 2020 to December 2022,and the 106 cases were finally included after screening.According to the random numbers,they were divided into Chinese medicine group(treatment with modified Guizhi Fuling pills in the basic group,53 cases)and basic group(ethinyl estradiol cyproterone tablets and letrozole tablets,53 cases).The general clinical data and endocrine and metabolic characteristics of all patients were analyzed,and the clinical efficacy,changes of hormone levels,menstrual improvement and pregnancy outcome of in vitro fertilization-embryo transfer(IVF-ET)were observed in the two groups.Results There were no differences in age,body mass index(BMI),waist-hip ratio(WHR),Ferriman-Gallway(F-G)score,global acne grading system(GAGS)score,and left and right ovarian volume size between the two groups(P>0.05).The total effective rate of the Chinese medicine group was higher than that of the basic group(P<0.05).After treatment,follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),testosterone(T)levels in traditional Chinese medicine group were better than those in basic group.The improvement of menstruation in traditional Chinese medicine group was better than that in basic group,and the difference was statistically significant(P<0.05).Ovum number,embryo number fertilization rate,excellent embryo rate and clinical pregnancy rate in traditional Chinese medicine group were higher than those in basic group,and the differences were statistically significant(P<0.05).Conclusion For the patients with phlegm-stasis interjunction PCOS,the clinical efficacy of modified Guizhi Fuling pills was superior to conventional treatment,which could effectively adjust the LH and T hormone levels,improve menstrual condition and reproductive function,and improve the fert

关 键 词：多囊卵巢综合征 痰瘀互结型 桂枝茯苓丸 

分 类 号：R271[医药卫生—中医妇科学]