自拟退黄颗粒治疗湿热郁蒸型新生儿高胆红素血症的临床效果  

Clinical Effect of Tuihuang Granules Draft by Oneself in the Treatment of Hyperbilirubinemia in Newborns with Dampness-heat Depression and Steaming Type

作　　者：王玉光 林德湘 郑炜清 WANG Yuguang;LIN Dexiang;ZHENG Weiqing(Traditional Chinese Medicine Hospital of Ningde,Ningde 352100,China;不详)

机构地区：[1]宁德市中医院,福建宁德352100

出　　处：《中外医学研究》2024年第13期1-4,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：福建中医药大学校管临床专项资助项目(XB2022094)。

摘　　要：目的:探究自拟退黄颗粒治疗湿热郁蒸型新生儿高胆红素血症的临床效果。方法:选取2020年1月—2023年8月宁德市中医院收治的80例湿热郁蒸型高胆红素血症新生儿作为研究对象。根据随机数表法将其分为对照组及试验组,各40例。对照组给予常规治疗,试验组给予自拟退黄颗粒。比较两组临床疗效,治疗前后中医症候积分,治疗前、治疗3 d后、治疗5 d后的经皮胆红素值,黄疸消退时间及不良反应。结果:试验组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组皮肤黄染、巩膜黄染、小便颜色、大便次数、奶量、烦躁评分均降低,试验组皮肤黄染、巩膜黄染、小便颜色、大便次数、奶量、烦躁评分均低于对照组,差异有统计学意义(P<0.05)。治疗3 d、5 d后,两组经皮胆红素值均下降,试验组经皮胆红素值均低于对照组,差异有统计学意义(P<0.05)。试验组黄疸消除时间短于对照组,差异有统计学意义(t=6.438,P<0.001)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:采用自拟退黄颗粒治疗新生儿高胆红素血症可提升疗效,降低中医症候积分、经皮胆红素水平并缩短黄疸消退时间,且不增加不良反应发生情况。Objective:To investigate the clinical effect of Tuihuang Granules draft by oneself in the treatment of hyperbilirubinemia in newborns with dampness-heat depression and steaming type.Method:Eighty newborns with damp-heat depression and steaming type hyperbilirubinemia treated in Traditional Chinese Medicine Hospital of Ningde from January 2020 to August 2023 were selected as the study objects.According to the method of random number table,they were divided into control group and experimental group,40 cases in each group.The control group was given conventional treatment,and the experimental group was given self-designed Tuihuang Granules.The clinical efficacy,traditional Chinese medicine syndrome score before and after treatment,percutaneous bilirubin value before treatment,after 3 d of treatment and after 5 d of treatment,jaundice resolution time and adverse reactions were compared between the two groups.Result:The total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,skin yellowing,sclera yellowing,urine color,stool frequency,milk volume and irritability score of both groups were decreased,and skin yellowing,sclera yellowing,urine color,stool frequency,milk volume and irritability score of experimental group were lower than those of control group,the differences were statistically significant(P<0.05).After 3 d and 5 d of treatment,the percutaneous bilirubin value of both groups decreased,and the percutaneous bilirubin value of experimental group was lower than that of control group,the differences were statistically significant(P<0.05).The elimination time of jaundice in experimental group was shorter than that in control group,the difference was statistically significant(t=6.438,P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Applying self-made Tuihuang Granules to treat neonatal hyperbilirubinemia can significantly improve the therapeut

关 键 词：新生儿高胆红素血症 湿热郁蒸型 退黄颗粒 疗效 

分 类 号：R272[医药卫生—中医儿科学]