苯磺酸瑞马唑仑复合低剂量丙泊酚全麻对腹腔镜胆囊切除术患者的影响  

Effect of Remimazolam Tosilate Combined with Low-dose Propofol General Anesthesia on Patients Undergoing Laparoscopic Cholecystectomy

作　　者：宋吉玲 鹿桂波 范海萍 SONG Jiling;LU Guibo;FAN Haiping(Zhucheng People's Hospital,Zhucheng 262200,China;不详)

机构地区：[1]诸城市人民医院,山东诸城262200

出　　处：《中外医学研究》2024年第13期29-33,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨苯磺酸瑞马唑仑复合低剂量丙泊酚全麻对腹腔镜胆囊切除术患者的影响。方法:选取2023年1—12月诸城市人民医院收治的100例腹腔镜胆囊切除术患者。根据随机数表法将其分为研究组和对照组,各50例。对照组给予低剂量丙泊酚麻醉维持,研究组在对照组基础上给予苯磺酸瑞马唑仑维持麻醉。比较两组苏醒质量,不良反应,麻醉后5 min(T_(1))、术后1 h(T_(2))和术后6 h(T_(3))血流动力学,T_(2)、T_(3)应激指标,麻醉质量及舒适度。结果:研究组苏醒时间、定向力恢复时间和拔管时间均早于对照组,T_(3)视觉模拟评分法(visual analogue scale,VAS)评分低于对照组,差异有统计学意义(P<0.05)。研究组术后不良反应发生率低于对照组,差异有统计学意义(P<0.05)。研究组T_(3)时的心率和平均动脉压均高于对照组,差异有统计学意义(P<0.05)。T_(3),两组丙二醛(malondialdehyde,MDA)降低,超氧化物歧化酶(superoxide dismutase,SOD)升高,研究组MDA低于对照组,SOD高于对照组,差异有统计学意义(P<0.05)。研究组完全运动阻滞时间和麻醉恢复时间均早于对照组,差异有统计学意义(P<0.05)。术后12 h(T_(4)),两组生理状态、心理精神、环境适应、社会文化评分均升高,研究组生理状态、心理精神、环境适应、社会文化评分均高于对照组,差异有统计学意义(P<0.05)。结论:苯磺酸瑞马唑仑复合低剂量丙泊酚全麻在腹腔镜胆囊切除术中的应用效果较好,能够促使患者血流动力学稳定,减轻术后疼痛,提高苏醒质量,缓解氧化应激刺激,加快预后康复,并降低不良反应发生风险,实用性和安全性更高。Objective:To explore the effect of Remimazolam Tosilate combined with low-dose Propofol general anesthesia on patients undergoing laparoscopic cholecystectomy.Method:A total of 100 patients with laparoscopic cholecystectomy treated in Zhucheng People's Hospital from January to December 2023 were selected.According to the method of random number table,the patients were divided into study group and control group,50 cases in each group.The control group was given low-dose Propofol anesthesia maintenance,while the study group was given Remimazolam Tosilate anesthesia maintenance on the basis of control group.The quality of recovery,adverse reactions,hemodynamics at 5 min after anesthesia(T_(1)),1 h after surgery(T_(2))and 6 h after surgery(T_(3)),T_(2) and T_(3) stress indexes,anesthesia quality and comfort were compared between the two groups.Result:The recovery time,orientation recovery time and extubation time of the study group were all earlier than those of the control group,and the score of visual analogue scale(VAS)at T_(3) was lower than that of the control group,the differences were statistically significant(P<0.05).The incidence of postoperative adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).The heart rate and mean arterial pressure of the study group at T_(3) were higher than those of the control group,and the differences were statistically significant(P<0.05).T_(3),malondialdehyde(MDA)decreased and superoxide dismutase(SOD)increased in the two groups,MDA in the study group was lower than that in the control group and SOD was higher than that in the study group,the differences were statistically significant(P<0.05).Complete motor block time and anesthesia recovery time in the study group were earlier than those in the control group,and the differences were statistically significant(P<0.05).At 12 h after surgery(T_(4)),the scores of physiological state,psychological spirit,environmental adaptation and social culture in both

关 键 词：苯磺酸瑞马唑仑 低剂量丙泊酚全麻 腹腔镜胆囊切除术 苏醒质量 血流动力学 氧化应激 

分 类 号：R614[医药卫生—麻醉学]