紫杉醇药物涂层球囊扩张血管成形术治疗下肢ASO患者的效果及对术后再狭窄的影响  

Effect of Paclitaxel Drug Coated Balloon Dilation Angioplasty in the Treatment of Lower Extremity ASO and Its Impact on Postoperative Restenosis

作　　者：尹志达 陈铃雄 林峰 张旭明 YIN Zhida;CHEN Lingxiong;LIN Feng;ZHANG Xuming(Mindong Hospital Affiliated to Fujian Medical University,Fu’an 355000,China;不详)

机构地区：[1]福建医科大学附属闽东医院,福建福安355000

出　　处：《中外医学研究》2024年第13期103-107,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨下肢动脉硬化闭塞症(ASO)采取紫杉醇药物涂层球囊(DCB)扩张血管成形术治疗的效果及对术后再狭窄的影响。方法:回顾性分析2020年1月—2023年1月福建医科大学附属闽东医院收治的60例下肢ASO患者的临床资料,按患者治疗意愿分为对照组(普通球囊扩张血管成形术,n=28)和观察组(紫杉醇DCB扩张血管成形术,n=32)。比较两组术前、术后和随访6个月Rutherford分级、动脉硬化指标、足背动脉血流动力学指标变化,并比较随访6个月内Ⅰ期通畅率、再狭窄率及并发症发生率。结果:观察组术后、随访6个月Rutherford分级、动脉硬化指标、足背动脉血流动力学指标较术前明显改善,对照组术后、随访6个月动脉硬化指标、足背动脉血流动力学指标较术前明显改善,术后Rutherford分级较术前有明显改善,观察组随访6个月上述各指标均优于对照组,差异有统计学意义(P<0.05)。随访6个月内,两组Ⅰ期通畅率比较,差异无统计学意义(P>0.05);观察组再狭窄率、并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论:紫杉醇DCB扩张血管成形术与普通球囊扩张血管成形术治疗下肢ASO的近期效果相当,但紫杉醇DCB扩张血管成形术可有效改善术后血流动力学和预防动脉硬化,减少血管再狭窄和并发症发生。Objective:To investigate the effect of Paclitaxel drug coated balloon(DCB)dilation angioplasty in the treatment of lower extremity arteriosclerotic occlusion(ASO)and its impact on postoperative restenosis.Method:The clinical data of 60 patients with lower extremity ASO who admitted to Mindong Hospital Affiliated to Fujian Medical University from January 2020 to January 2023 were retrospectively analyzed,they were divided into the control group(ordinary balloon dilatation angioplasty,n=28)and the observation group(Paclitaxel DCB dilatation angioplasty,n=32)according to the patients'willingness to treat.The changes of Rutherford classification,arteriosclerosis indexes and hemodynamic indexes of dorsalis pedis artery were compared between two groups before and after operation and 6 months of follow-up,the phaseⅠpatency rate,restenosis rate and complication rate were compared between two groups within 6 months of follow-up.Result:The Rutherford classification,arteriosclerosis indexes and hemodynamic indexes of dorsalis pedis artery in the observation group were significantly improved after operation and 6 months of follow-up compared with those before operation,the arteriosclerosis indexes and hemodynamic indexes of dorsalis pedis artery in the control group were significantly improved after operation and 6 months of follow-up compared with those before operation,the Rutherford classification after operation was significantly improved compared with that before operation,the above indexes in the observation group after 6 months of follow-up were better than those in the control group,and the differences were statistically significant(P<0.05).During the 6-month follow-up,there was no significant difference in the phaseⅠpatency rate between two groups(P>0.05);the restenosis rate and total incidence of complications in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:The short-term effect of Paclitaxel DCB dilation angioplasty is co

关 键 词：紫杉醇 药物涂层球囊 扩张血管成形术 动脉硬化闭塞 血流动力学 并发症 

分 类 号：R654.4[医药卫生—外科学]