血清碱性磷酸酶在心血管疾病中的研究进展  

Research progress of serum alkaline phosphatase in cardiovascular disease

作　　者：熊星 王志梅 张宁 温霞 XIONG Xing;WANG Zhimei;ZHANG Ning;WEN Xia(Inner Mongolia Clinical Medical College,Inner Mongolia Medical University,Hohhot,Inner Mongolia 010020,P.R.China;Department of Emergency,Inner Mongolia Autonomous Region People’s Hospital,Hohhot,Inner Mongolia 010020,P.R.China)

机构地区：[1]内蒙古医科大学内蒙古临床医学院,呼和浩特010020 [2]内蒙古自治区人民医院急诊科,呼和浩特010020

出　　处：《华西医学》2024年第4期645-648,共4页West China Medical Journal

摘　　要：血清碱性磷酸酶(alkaline phosphatase,ALP)长期以来作为肝、肾、骨的标志物。目前,越来越多证据表明血清ALP与心血管疾病(cardiovascular disease,CVD)之间也具有相关性。研究显示,血清ALP通过各种机制影响血管内皮细胞功能、诱导焦磷酸盐变化以加速血管钙化和促进心脏纤维化。因此,该文结合相关研究对血清ALP在CVD中的潜在价值进行综述,揭示血清ALP与CVD之间的具体联系,以期为CVD的防治提供新的思路。Serum alkaline phosphatase(ALP)has long been used as a biomarker for the liver,kidney,and bone.Currently,increasing evidence suggests a correlation between serum ALP and cardiovascular disease(CVD).Research has shown that serum ALP affects endothelial cell function and induces changes in pyrophosphate through various mechanisms to accelerate vascular calcification and promote cardiac fibrosis.Therefore,this article reviews the potential value of serum ALP in CVD through relevant research,revealing the specific relationship between serum ALP and CVD,in order to provide new ideas for the prevention and treatment of CVD.

关 键 词：血清碱性磷酸酶 心血管疾病 血管内皮细胞功能障碍 血管钙化 心脏纤维化 

分 类 号：R54[医药卫生—心血管疾病]