性别差异与膝骨关节炎发病相关性的研究进展  

Research progress on the correlation between gender differences and the incidence of knee osteoarthritis

作　　者：刘林枫 胡笑燊 史鹏博[3] 汪利合[3] LIU Linfeng;HU Xiaoshen;SHI Pengbo;WANG Lihe(College of Orthopedics and Traumatology,Henan University of Chinese Medicine,Zhengzhou,Henan 450046,P.R.China;Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611137,P.R.China;Department of Orthopaedics and Traumatology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450003,P.R.China)

机构地区：[1]河南中医药大学骨伤学院,郑州450046 [2]成都中医药大学,成都611137 [3]河南中医药大学第一附属医院骨伤科,郑州450003

出　　处：《华西医学》2024年第4期649-653,共5页West China Medical Journal

基　　金：国家自然科学基金(82205239);河南省科学技术厅重点研发与推广专项(232102310474);河南省中医药科学研究专项课题(2023ZY2046)。

摘　　要：膝骨关节炎(knee osteoarthritis,KOA)是常见的退行性关节疾病之一,好发于中老年人群,其表现出明显的性别差异,女性患病率明显高于男性,严重影响患者的生活质量,但目前国内外针对性别差异与KOA发病相关性的研究报道较少。因此,该文将从激素水平、解剖-生物力学特性、基因、肥胖及运动-肌肉因素5个方面进行归纳与分析,探讨KOA发病相关性别差异的潜在原因,通过全面梳理研究进展,旨在为临床上KOA基于性别的个性化治疗提供理论依据。Knee osteoarthritis(KOA)is one of the common degenerative joint diseases,which is more common in the middle-aged and elderly population.It shows significant gender differences,with a significantly higher incidence rate in women than in men,seriously affecting the quality of life of patients.However,there are few research reports on the correlation between gender differences and the incidence of KOA both domestically and internationally.Therefore,this article will summarize and analyze the potential causes of gender differences related to the incidence of KOA from five aspects:hormone levels,anatomical biomechanical characteristics,genes,obesity,and exercise-muscle factors.Through a comprehensive review of research progress,the aim is to provide a theoretical basis for gender based personalized treatment of KOA in clinical practice.

关 键 词：膝骨关节炎 性别差异 发病机制 研究进展 

分 类 号：R684.3[医药卫生—骨科学]