颅内动脉支架术后再狭窄的血液影响因素分析与探讨  

Analysis and Discussion of Blood Factors Affecting Intracranial Artery In-Stent Restenosis

作　　者：吴瀚博 高莹 WU Han-bo;GAO Ying(Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital Zhoushan Branch)

机构地区：[1]上海交通大学医学院附属瑞金医院舟山分院

出　　处：《医院管理论坛》2024年第4期52-57,73,共7页Hospital Management Forum

摘　　要：目的探讨颅内动脉狭窄支架置入术后相关血液生物标志物与进行性动脉粥样硬化再狭窄的关系。方法选取2020年1月—2022年8月在我院进行颅内动脉狭窄支架置入术的140例患者为研究对象。统计术后12个月随访期间症状性颅内动脉狭窄支架置入术后复发性缺血性脑血管事件的发生情况,将其分为复发性/缺血性卒中(n=15)和非复发性/缺血性卒(n=125)。对随访期间血液生物指标及症状等进行统计学分析。结果在单因素分析中,平均血小板体积等与复发性/脑缺血事件相关(p<0.05)。多元Logistic回归分析提示,支架内再狭窄(ISR)是复发性/缺血性卒中发生的重要危险因素。结论ISR是发生复发性卒中或短暂性脑缺血发作的重要危险因素,而术后测试的血液生物标志物与ISR正相关。Objective To investigate the relationship between related blood biomarkers and progressive atherosclerotic restenosis after stent implantation for intracranial artery stenosis.Methods A total of 140 patients who underwent stenting for intracranial artery stenosis in our hospital from January 2020 to August 2022 were selected for the study.The occurrence of recurrent ischemic cerebrovascular events after symptomatic intracranial artery stenosis stenting during the 12-month postoperative follow-up period was counted and classified into recurrent/ischemic stroke(n=15)and non-recurrent/ischemic stroke(n=125).Statistical analysis of biological indicators and symptoms during the follow-up period was performed.Results In univariate analysis,mean platelet volume was associated with recurrent/ischemic events(p<0.05).Multiple logistic regression analysis suggested that in-stent restenosis(ISR)was a significant risk factor for recurrent/ischemic stroke.Conclusions ISR is an important risk factor for the development of recurrent stroke or transient ischemic attack,and blood biomarkers tested after surgery are positively associated with ISR.

关 键 词：颅内动脉粥样硬化性狭窄 支架置入术 支架内再狭窄 血液生物标志物 

分 类 号：R197.3[医药卫生—卫生事业管理]