家养动物增强子和超级增强子的研究进展  

Advances in Enhancers and Super Enhancers in Domestic Animals

作　　者：章露浩 黄宣凯 康佳威 李云娜 郑怡雯 孟芳荣 王志鹏[1,2,4] 狄生伟 ZHANG Luhao;HUANG Xuankai;KANG Jiawei;LI Yunna;ZHENG Yiwen;MENG Fangrong;WANG Zhipeng;DI Shengwei(College of Animal Science and Technology,Northeast Agricultural University,Heilongjiang Harbin 150000,China;Bioinformatics Center,Northeast Agricultural University,Heilongjiang Harbin 150000,China;Branch of Animal Husbandry and Veterinary,Heilongjiang Academy of Agricultural Sciences,Heilongjiang Qiqihar 161000,China;Da Bei Nong Food Group,Breeding Center,Heilongjiang Harbin 150000,China)

机构地区：[1]东北农业大学动物科学技术学院,黑龙江哈尔滨150000 [2]东北农业大学生物信息中心,黑龙江哈尔滨150000 [3]黑龙江省农业科学院畜牧兽医分院,黑龙江齐齐哈尔161000 [4]大北农食品集团,黑龙江哈尔滨150000

出　　处：《中国畜牧杂志》2024年第5期80-88,共9页Chinese Journal of Animal Science

基　　金：国家自然科学基金面上项目(32070571);黑龙江省自然科学基金联合引导项目(LH2022C026);黑龙江省自然科学基金联合引导项目(LH2022C094);黑龙江省农业科学院畜牧兽医分院自拟课题(ZNKT-202210)。

摘　　要：增强子是一类重要的顺式作用元件,通过调控其靶基因的时空表达在动物发育过程中起着重要作用。超级增强子由增强子集群组成,具有比普通增强子更为重要的生物学功能,研究增强子和超级增强子有助于揭示基因组内部复杂的工作原理。本文围绕家养动物增强子和超级增强子全基因组水平上的筛选、潜在功能、活性分析以及变异研究进行综述,以期为进一步开展动物功能基因组学的研究提供参考。Enhancers are an important class of cis-acting elements that play an important role in animal development by regulating the temporal and spatial expression of their target genes.Super enhancers are composed of enhanced subsets and have more important biological functions than ordinary enhancers.Studying enhancers and super enhancers helps to reveal the complex inner workings of the genome.This review focuses on the genome-wide screening,potential functions,activity analysis and variation studies of enhancers and super enhancers in domestic animals,in order to provide references for further research on animal functional genomics.

关 键 词：增强子 超级增强子 家养动物 功能基因组学 

分 类 号：S813.1[农业科学—畜牧学]