自噬在冠状动脉粥样硬化性心脏病中的研究进展  

Research Progress of Autophagy in Coronary Atherosclerotic Heart Disease

作　　者：章晶晶 黄鹤[1] ZHANG Jingjing;HUANG He(Department of Cardiology,Renmin Hospital of Wuhan University,Hubei Key Laboratory of Cardiology,Cardiovascular Research Institute of Wuhan University,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院心内科,心血管病湖北省重点实验室,武汉大学心血管病研究所,湖北武汉430060

出　　处：《心血管病学进展》2024年第4期312-316,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82070330)。

摘　　要：冠状动脉粥样硬化性心脏病(CHD)是全球最常见的死亡原因。自噬是一种生存机制,是指将细胞质成分吞噬到双膜自噬体中,随后将其传递给溶酶体降解,从而通过重新利用消化的细胞成分使细胞存活的过程。细胞自噬是适应性反应,对细胞生长、存活和细胞稳态至关重要。近期发现,自噬与CHD的发生发展密切相关。正常的自噬对心肌细胞有保护作用,自噬不足或自噬过度会加重CHD的进展。现对自噬在CHD中的研究进展做一综述。Coronary atherosclerotic heart disease(CHD)is the most common cause of death worldwide.Autophagy,or macroautophagy,is a survival mechanism that refers to the process of phagocytosis of cytoplasmic components into the double-membrane autophagosome,which is subsequently passed on to lysosome for degradation,thereby keeping cells alive by recycling the digested cellular components.Autophagy is an adaptive response that is essential for cell growth,survival and homeostasis.Recently,autophagy has been found to be closely related to the occurrence and development of CHD.Normal autophagy has a protective effect on cardiomyocytes,and insufficient or excessive autophagy can aggravate the progression of CHD.The article reviews the research progress of autophagy in CHD.

关 键 词：冠状动脉粥样硬化性心脏病 细胞自噬 正向调节作用 负向调节作用 相关治疗 

分 类 号：R541.4[医药卫生—心血管疾病]