白细胞介素家族与心房颤动的研究进展  

Interleukin Family and Atrial Fibrillation

作　　者：张晓婷 郭衍楷 汤宝鹏[1] ZHANG Xiaoting;GUO Yankai;TANG Baopeng(Department of Cardiac Pacing Electrophysiology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院心脏起搏电生理科,新疆乌鲁木齐830000

出　　处：《心血管病学进展》2024年第4期340-344,共5页Advances in Cardiovascular Diseases

基　　金：新疆维吾尔自治区自然科学基金青年科学基金(2022D01C767);省部共建中亚高发病成因与防治国家重点实验室(SKL-HIDCA-2022-XXG4)。

摘　　要：心房颤动是一种病理生理学机制复杂的心律失常。大量的临床试验及动物实验表明炎症因子介导的心房结构重构及电重构是诱发心房颤动的重要病理生理学基础,其中白细胞介素(IL)家族与心房颤动的关系最为密切。现简要概述IL-1β、IL-6、IL-10、IL-17和IL-22与心房颤动之间的相关性以及目前已发现的IL受体拮抗剂在心血管疾病中的应用。Atrial fibrillation is a kind of arrhythmia with complex pathophysiological mechanism.A large number of clinical trials and animal experiments have shown that atrial structural remodeling and electrical remodeling mediated by inflammatory factors are important pathophysiological basis for inducing atrial fibrillation,and the interleukin(IL)family is most closely related to atrial fibrillation.This article briefly reviews the relationship between IL-1β,IL-6,IL-10,IL-17,and IL-22 and atrial fibrillation,and the application of IL-receptor antagonists in cardiovascular disease.

关 键 词：心房颤动 炎症因子 白细胞介素 心房重构 电重构 

分 类 号：R541.75[医药卫生—心血管疾病]