甘油三酯葡萄糖指数评估不同性别中年人群发生冠心病的价值  

The value of triglyceride-glucose index in evaluating coronary heart disease in middle-aged people of different genders

作　　者：李其华[1] 陈慧生[1,2] 陈见红[1,2] LI Qi-hua;CHEN Hui-sheng;CHEN Jian-hong(Department of General Medicine,Liuzhou People’s Hospital,Liuzhou 545006,China;Department of Cardiology,Liuzhou People’s Hospital,Liuzhou 545006,China)

机构地区：[1]柳州市人民医院全科医学科,广西柳州市545006 [2]柳州市人民医院心血管内科,广西柳州市545006

出　　处：《中国心血管病研究》2024年第5期448-453,共6页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨甘油三酯葡萄糖指数(TyGindex)评估不同性别中年人群发生冠心病的价值。方法选取2015年1月至2022年12月在柳州市人民医院行冠状动脉造影的中年人群433例为研究对象。收集其一般资料、实验室检查指标和冠状动脉造影结果。根据TyGindex中位数将不同性别人群分为低TyG index组(男性107例;女性106例)、高TyGindex组(男性111例;女性109例)。采用多因素logistic回归分析不同性别中年人群发生冠心病的影响因素。采用ROC曲线评估TyGindex对不同性别中年人群发生冠心病的预测价值。结果多因素logistic回归分析结果显示,年龄(OR=1.103,95%CI 1.043~1.166)、吸烟史(OR=2.173,95%CI 1.199~3.938)、HDL-C(OR=0.244,95%CI 0.062~0.961)是中年男性人群发生冠心病的独立影响因素(P<0.05);年龄(OR=1.121,95%CI 1.032~1.218)、TyGindex(OR=2.606,95%CI1.220~5.567)是中年女性人群发生冠心病的独立影响因素(P<0.05)。ROC曲线分析结果显示,TyGindex预测中年男性和女性人群发生冠心病的曲线下面积分别为0.603(95%CI 0.526~0.680,P=0.009)、0.756(95%CI 0.686~0.826,P<0.001)。结论TyGindex升高不是中年男性人群发生冠心病的独立危险因素,预测价值低;而TyGindex升高是中年女性人群发生冠心病的独立危险因素,具有中等预测价值。Objective To investigate the value of triglyceride-glucose(TyG)index in evaluating coronary heart disease(CHD)in middle-aged people of different genders.Method A total of 433 middle-aged people who underwent coronary angiography in Liuzhou People’s Hospital from January 2015 to December 2022 were selected as the research subjects.The general data,laboratory examination indicators and coronary angiography results of the subjects were collected.The research subjects of different genders were divided into low TyG index group(male:107 cases;female:106 cases)and high TyG index group(male:111 cases;female:109 cases)according to median TyG index.Multivariate logistic regression were used to analyze the influencing factors of CHD in middle-aged people of different genders.ROC curve was used to evaluate the value of TyG index in predicting CHD in middle-aged people of different genders.Results Multivariate logistic regression analysis showed that age(OR=1.103,95%CI 1.043-1.166),smoking history(OR=2.173,95%CI 1.199-3.938)and HDL-C(OR=0.244,95%CI 0.062-0.961)were independent influencing factors of CHD in middle-aged male people(P<0.05);age(OR=1.121,95%CI 1.032-1.218)and TyG index(OR=2.606,95%CI 1.220-5.567)were independent influencing factors of CHD in middle-aged female people(P<0.05).ROC curve analysis showed that the area under the curve of TyG index in predicting CHD in middle-aged male and female people were[0.603(95%CI 0.526-0.680),P=0.009]and[0.756(95%CI 0.686-0.826),P<0.001]respectively.Conclusion Increased TyG index is not an independent risk factor for CHD in middle-aged male people,with low predictive value.However,increased TyG index is an independent risk factor for CHD in middle-aged female people,with medium predictive value.

关 键 词：甘油三酯葡萄糖指数 中年人群 冠心病 预测价值 性别 

分 类 号：R541.4[医药卫生—心血管疾病]