碱催化2-取代苯并噁唑类化合物合成  

Synthesis of 2-Substituted Benzoxazole Compounds

作　　者：查鑫文 陆志伟 朱慧彤 刘娥[1] Zha Xinwen;Lu Zhiwei;Zhu Huitong;Liu E(College of Chemical Engineering and Pharmacy,Jingchu University of Technology,Jingmen 448000,China)

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《山东化工》2024年第8期42-44,共3页Shandong Chemical Industry

基　　金：湖北省大学生科技创新训练项目。

摘　　要：苯并噁唑是一类重要的含氮氧杂环化合物,具有良好的生物活性。苯并噁唑化合物中2位官能团对生理活性影响最大,因此,研究2-取代苯并噁唑类化合物的合成具有重要意义。以2-氨基苯酚为起始原料,在碱性条件下合成了5种2-取代苯并噁唑类化合物,产物结构经1HNMR确证。Benzoxazole is an important class of nitrogen-containing heterocyclic compounds with excellent biological activity.The 2-functional group in benzoxazole compounds has the greatest impact on physiological activity,therefore,studying the synthesis of 2-substituted benzoxazole compounds is of great significance.This article synthesized five 2-substituted benzoxazole compounds using 2-aminophenol as the starting material under alkaline conditions,and the product structures were confirmed by 1HNMR.

关 键 词：碱 苯并噁唑 2-取代 合成 

分 类 号：O62[理学—有机化学]