老年肺源性心脏病合并冠心病患者超声参数与心肌损伤标志物的相关性分析  

Correlation analysis of ultrasound parameters with myocardial injury markers in elderly patients with pulmonary heart disease complicated with coronary heart disease

作　　者：张愉涵 赵梦鸽 Zhang Yuhan;Zhao Mengge(Department of Geriatric Medicine,Zhengzhou Jinshui District General Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市金水区总医院老年医学科,郑州450000

出　　处：《实用医技杂志》2024年第4期254-257,共4页Journal of Practical Medical Techniques

摘　　要：目的分析老年肺源性心脏病(CPHD)合并冠心病(CHD)患者超声参数与心肌损伤标志物的相关性。方法选定郑州市金水区总医院老年医学科2022年11月至2023年11月就诊的200例老年CPHD患者,根据是否合并CHD将其分为2组,80例合并CHD的患者设为观察组,120例未合并CHD的患者设为对照组。均给予心脏彩色多普勒超声检查,抽取空腹静脉血检测心肌损伤标志物,比较2组心脏彩超参数[左室收缩末期内径(LVESD)、舒张末期内径(LVEDD)、左室射血分数(LVEF)]、心肌损伤标志物[肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)],比较老年CPHD合并CHD患者中不同美国纽约心脏协会(NYHA)分级组心脏彩超参数、心肌损伤标志物,Pearson分析心脏彩超参数与心肌损伤标志物的相关性。结果观察组LVESD、LVEDD均高于对比组(P<0.001),观察组LVEF低于对比组(P<0.05)。观察组血清cTnI、CK-MB水平均高于对比组(P<0.001)。Ⅲ~Ⅳ级组LVESD、LVEDD均高于Ⅰ~Ⅱ级组(P<0.001),Ⅲ~Ⅳ级组LVEF低于Ⅰ~Ⅱ级组(P<0.001)。Ⅲ~Ⅳ级组血清cTnI、CK-MB水平均高于Ⅰ~Ⅱ级组(P<0.001)。LVESD、LVEDD与cTnI、CK-MB均呈正相关性(r=0.382、0.391、0.376、0.390,P均<0.001),LVEF与cTnI、CK-MB均呈负相关性(r=-0.371、-0.383,P均<0.001)。结论老年CPHD合并CHD患者LVESD、LVEDD及血清cTnI、CK-MB水平较高,LVEF较低,LVESD、LVEDD、LVEF与cTnI、CK-MB存在一定的相关性,可辅助临床对患者病情作出全面评价。Objective To analyze the correlation between ultrasonic parameters and myocardial injury markers in elderly patients with pulmonary heart disease(CPHD)complicated with coronary heart disease(CHD).Methods A total of 200 elderly CPHD patients from the Department of Geriatric Medicine,Jinshui District General Hospital of Zhengzhou City from November 2022 to November 2023 were selected and divided into two groups according to whether they had CHD or not.Eighty patients with CHD were set as observation group,and 120 patients without CHD were set as comparison group.All patients were given cardiac color doppler ultrasonography,and fasting venous blood was collected to detect myocardial injury markers.Cardiac color Doppler ultrasonography parameters(left ventricular end-systolic diameter(LVESD),end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and myocardial injury markers[troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)]of the two groups were compared.Cardiac color doppler ultrasound parameters and myocardial injury markers in different New York Heart Association(NYHA)classification groups in elderly CPHD patients with CHD were compared,and the correlation between cardiac color Doppler ultrasound parameters and myocardial injury markers was analyzed by Pearson correlation aralysis method.Results LVESD and LVEDD in observation group were higher than those in comparison group(P<0.05),and LVEF in observation group was lower than that in comparison group(P<0.001).The levels of serum cTnI and CK-MB in observation group were higher than those in control group(P<0.001).LVESD and LVEDD in gradeⅢ~Ⅳgroup were higher than those in gradeⅠ~Ⅱgroup(P<0.001),and LVEF in gradeⅢ~Ⅳgroup was lower than that in gradeⅠ~Ⅱgroup(P<0.001).The levels of serum cTnI and CK-MB in gradeⅢ~Ⅳgroup were higher than those in gradeⅠ~Ⅱgroup(P<0.001).LVESD and LVEDD were positively correlated with cTnI and CK-MB(r=0.382,0.391,0.376,0.390,all P<0.001).And LVEF was negatively correlated with cTnI and CK-MB(r=-0.

关 键 词：肺心病 冠心病 超声心动描记术 多普勒 心肌损伤 

分 类 号：R445.1[医药卫生—影像医学与核医学] R541.5[医药卫生—诊断学] R541.4[医药卫生—临床医学]