311例化妆品皮肤不良反应临床特征分析  

Clinical characteristics analysis of 311 cases of cosmetic skin adverse reactions

作　　者：胡范文 刘文文 张峰[1] 刘岩松[1] 于德宝[1] HU Fan-wen;LIU Wen-wen;ZHANG Feng;LIU Yan-song;YU De-bao(Jinan Dermatology Prevention and Control Hospital,Shandong Province,250001,China;Shandong Center for Adverse Drug Reaction Monitoring,Shandong Province,250013,China)

机构地区：[1]济南市皮肤病防治院,山东济南250001 [2]山东省药品不良反应监测中心,山东济南250013

出　　处：《中国医疗美容》2024年第4期67-70,共4页China Medical Cosmetology

基　　金：山东省药品不良反应监测中心资助项目(药化-2023-SDADR-047)。

摘　　要：目的探究不同剂型化妆品皮肤不良反应患者的临床特征,为化妆品皮肤不良反应监管和防治提供资料。方法回顾性分析2020年1月至2023年7月我院化妆品皮肤不良反应患者的一般情况、临床资料、化妆品产品剂型等信息,汇总数据并进行统计分析。结果311例患者中,发病以女性(88.75%)为主,年龄主要集中在21-50岁(71.38%),临床特征以面部受累、瘙痒、红斑为主,临床类型以化妆品接触性皮炎最常见。共涉及7种产品剂型,膏霜乳皮肤不良反应(膏霜乳组)患者最多,占48.87%,其次为液体皮肤不良反应(液体组)患者占29.90%,贴、膜、含基材皮肤不良反应(贴膜组)患者占17.36%。以普通护肤类化妆品为主,占总化妆品类别的72.99%。特殊化妆品中以染发类最多(占总化妆品类别的8.04%)且剂型多数为膏霜乳(23/25)。结论不同剂型化妆品皮肤不良反应患者有一定的临床特征,可为化妆品皮肤不良反应监管和防治提供参考。Objective To explore the clinical characteristics of patients with skin adverse reactions caused by different dosage forms of cosmetics,providing informations for the supervision and prevention of skin adverse reactions caused by cosmetics.Method A retrospective analysis was conducted on the general condition,clinical data,cosmetic product dosage forms,and other information of patients withcosmetic skin adverse reactions who visited our hospital from January 2020 to July 2023.The data were collected and statistically analyzed.Result Among the 311 patients,the incidence was mainly female(88.75%),with the age mainly concentrated between 21 and 50 years old(71.38%).The clinical features are mainly facial involvement,itching and erythema.The most common clinical type was cosmetic contact dermatitis.There were a total of 7 product formulations involved,with the highest incidence of skin adverse reactions in the cream group(48.87%),followed by liquid group(29.90%)and mask group(17.36%).The cosmetics involved are mainly ordinary skincare categories,accounting for 72.99%of the total cosmetics category.Among special cosmetics,hair coloring was the most common type(accounting for 8.04%of the total cosmetics category),and the majority of formulations was cream(23/25).Conclusion Patients with skin adverse reactions caused by different dosage forms of cosmetics have certain clinical characteristics,which can provide reference for the supervision and prevention of skin adverse reactions caused by cosmetics.

关 键 词：化妆品 不良反应 剂型 接触性皮炎 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]