国医大师丁樱治疗过敏性紫癜用药规律研究  

Study on the Medication Law of National TCM Master Ding Ying in the Treatment of Henoch-Schönlein Purpura

作　　者：张博[1,2] 高敏[1,2] 任献青[1,2] 宋纯东[1,2] 郑肖庆 丁樱(指导)[1,2] ZHANG Bo;GAO Min;REN Xianqing;SONG Chundong;ZHENG Xiaoqing;DING Ying(Department of Pediatrics,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;School of Pediatrics,Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院儿科医院,河南郑州450000 [2]河南中医药大学儿科医学院,河南郑州450000

出　　处：《中国中医药信息杂志》2024年第6期47-53,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家重点研发计划-中医药现代化专项(2018YFC1704103);第七批全国老中医药专家学术经验继承项目(2022年);河南省中医药文化著作资助专项(2019KYXM-Z1107-49);河南省中医药科学研究专项课题(2022ZY1027、2023ZY2020)。

摘　　要：目的挖掘丁樱教授治疗过敏性紫癜的用药规律,探析丁樱教授治疗过敏性紫癜的学术思想与临床经验。方法选取2013年1月-2020年1月河南中医药大学第一附属医院丁樱教授儿科门诊的过敏性紫癜处方,通过名医传承一体化平台,建立药物-药物、药物-症状网络,对其核心药组及关联规律进行深层次分析。结果纳入病案195则,涉及585诊次、处方585首、中药153种,药物总频次为8017。药性以寒、温、平为主,药味以苦为主,归经以肝经、心经为主。药物权重等级分析显示,生地黄、当归、连翘、忍冬藤、牡丹皮、紫草、川芎、地肤子、海风藤、络石藤、徐长卿、雷公藤、薏苡仁、黄芩、水牛角、砂仁、白芍、浮萍、甘草为治疗过敏性紫癜的核心处方。药物-药物共现性分析显示,生地黄-当归、生地黄-牡丹皮、连翘-牡丹皮、地肤子-忍冬藤、川芎-忍冬藤、忍冬藤-当归、地肤子-连翘、牡丹皮-紫草、当归-牡丹皮、生地黄-连翘、连翘-川芎、生地黄-忍冬藤为治疗过敏性紫癜的常用药对;聚类分析显示出10个潜在药物群。结论丁樱教授治疗过敏性紫癜强调病、证、症相结合及对药的应用,临证施治遵循“祛邪安络”思想,善用清热解毒类药、清热祛风类药、清热祛湿类药以“祛邪”,善用活血凉血类药、养血通络类药以“安络”。Objective To explore the medication law of Professor Ding Ying in the treatment of Henoch-Schönlein purpura;To analyze Professor Ding Ying’s academic thought and clinical experience in the treatment of Henoch-Schönlein purpura.Methods Professor Ding Ying’s prescriptions for the treatment of Henoch-Schönlein purpura in The First Affiliated Hospital of Henan University of Chinese Medicine from January 2013 to January 2020 were selected.Through the analysis of the Integrated Platform for Inheriting Famous Doctors,drug-drug and drug-symptom networks were constructed,and in-depth analysis of its core drug groups and their associated patterns was conducted.Results Totally 195 cases were included in the study,involving 585 times of diagnosis and 585 prescriptions.153 kinds of Chinese materia medica were involved in the prescriptions,with a total frequency of 8017 times.The medicinal properties were mainly cold,warm and neutral,the medicinal taste was mainly bitter,and the meridians are mainly liver meridian and heart meridian.The analysis of drug weight grade showed that Rehmanniae Radix,Angelicae Sinensis Radix,Forsythiae Fructus,Lonicerae Japonicae Caulis,Moutan Cortex,Arnebiae Radix,Chuanxiong Rhizoma,Kochia Fructus,Piperis Kadsurae Caulis,Trachelospermi Caulis et Folium,Cynanchi Paniculati Radix et Rhizoma,Tripterygium wilfordii,Coicis Semen,Scutellariae Radix,Bubali Cornu,Amomi Fructus,Paeoniae Radix Alba,Spirodelae Herba and Glycyrrhizae Radix et Rhizoma were the core prescriptions for the treatment of Henoch-Schönlein purpura.Drug-drug co-occurrence analysis showed that Rehmanniae Radix-Angelicae Sinensis Radix,Rehmanniae Radix-Moutan Cortex,Forsythiae Fructus-Moutan Cortex,Kochia Fructus-Lonicera Japonicae Caulis,Chuanxiong Rhizoma-Lonicera Japonicae Caulis,Lonicerae Japonicae Caulis-Angelicae Sinensis Radix,Kochia Fructus-Forsythiae Fructus,Moutan Cortex-Arnebiae Radix,Angelicae Sinensis Radix-Moutan Cortex,Rehmanniae Radix-Forsythiae Fructus,Forsythiae Fructus,Rehmanniae Radix-Lonicera Japonicae Caulis

关 键 词：过敏性紫癜 数据挖掘 用药规律 丁樱 FangNet平台 

分 类 号：R2-05[医药卫生—中医学] R259.546