基于真实世界观察宣肺通窍针法治疗变应性鼻炎临床疗效  

Clinical Efficacy of Xuanfei Tongqiao Acupuncture in Treatment of Allergic Rhinitis Based on Real World

作　　者：曾春利 吕鹤群[2] 彭拥军 ZENG Chunli;LYU Hequn;PENG Yongjun(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Yancheng 224000,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学附属盐城中医院,江苏盐城224000

出　　处：《中国中医药信息杂志》2024年第6期141-149,共9页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：江苏省中医院高峰学术人才项目(k2021rc24);江苏省第六期“333高层次人才培养工程”项目(2022年);南京中医药大学自然科学基金(XZR2021023);江苏省研究生科研与实践创新计划(SJCX23_0899)。

摘　　要：目的基于真实世界研究回顾性分析宣肺通窍针法治疗变应性鼻炎(AR)的临床疗效。方法提取2021年1月-2022年10月南京中医药大学附属医院针灸康复科门诊医院信息系统临床数据及Excel记录的患者诊疗资料,根据纳排标准筛选数据。纳入数据通过计算受试者工作特征(ROC)曲线阈值,明确依据疗程分组的界值,将针刺患者分为针刺A组和针刺B组,治疗采用宣肺通窍针法。A组、B组使用倾向性评分匹配(PSM)使组间基线均衡可比,比较2组疗效、总有效率、鼻症状总分(TNSS)、鼻伴随症状总分(TNNSS)、不良事件及复发情况。对针刺组进行分层分析时,组间比较采用逆概率加权(IPTW)法,分别比较2组疗效、总有效率、TNSS、TNNSS、不良事件和复发情况,同时比较组内治疗前后TNSS、TNNSS。结果共收集209例患者数据,其中非针刺7例、针刺202例,根据ROC曲线特征,疗程<6周为针刺A组,疗程≥6周为针刺B组,2组病情比较差异有统计学意义(P<0.05)。通过PSM成功匹配66对患者,2组基线差异无统计学意义(P>0.05)。PSM后比较2组疗效、总有效率、治疗后TNSS和TNNSS及随访时TNSS,并对治疗后2组TNSS和TNNSS进行组内比较,差异均有统计学意义(P<0.01)。PSM前,2组复发率比较差异有统计学意义(P<0.05),2组PSM前后不良事件发生率及PSM后复发率比较差异无统计学意义(P>0.05)。对针刺患者按病情进行分层分析,轻度和中重度患者分别按疗程分为针刺A组和针刺B组,2组治疗前后TNSS、TNNSS组内比较差异有统计学意义(P<0.01)。对2组进行IPTW处理使基线均衡可比,2组疗效等级分布差异有统计学意义(P<0.05),但2组总有效率、治疗后及随访时TNSS和TNNSS、不良事件发生率及复发率比较差异均无统计学意义(P>0.05)。中重度患者2组疗效等级分布、总有效率、治疗后及随访时TNSS、TNNSS比较差异均有统计学意义(P<0.01),2组不良事件发生率、复发率比�Objective To retrospectively analyze the clinical efficacy of Xuanfei Tongqiao Acupuncture for treatment of allergic rhinitis(AR)based on real world studies.Methods Clinical data in the hospital information system of Acupuncture and Moxibustion Rehabilitation Department of the Affiliated Hospital of Nanjing University of Chinese Medicine from January 2021 to October 2022 and Excel sheet records were extracted.The data were screened according to the criteria.Based on the thresholds of receiver operating characteristic(ROC)curve,the treatment grouping thresholds were clarified.The acupuncture patients was divided into acupuncture group A and acupuncture group B,the treatment was Xuanfei Tongqiao Acupuncture.Groups A and B were compared using propensity score matching(PSM)to make the baseline balance comparable between groups.The efficacy,total effective rate,total nasal symptom score(TNSS),total non nasal symptoms score(TNNSS),adverse events,and recurrence were then compared between the two groups.In stratified analyses,the inverse probability of treatment weighting(IPTW)method was used for between-group comparisons.The efficacy,total effective rate,TNSS and TNNSS,incidence of adverse events,and recurrence were compared between the two groups,respectively.The TNSS and TNNSS before and after treatment within the group were also compared.Results A total of 209 patients’data were collected,including 7 non-acupuncture patients and 202 acupuncture patients,and the acupuncture patients was divided into acupuncture group A(<6 weeks of treatment)and acupuncture group B(≥6 weeks of treatment)according to the ROC curve characteristics,and there was a difference in comparing the conditions of the two groups(P<0.05).66 pairs of patients were successfully matched after PSM,and there was no significant difference between the two groups at baseline(P>0.05).After PSM,the efficacy,total effective rate,post-treatment TNSS and TNNSS and TNSS at the follow-up between the two groups were compared,and the post-treatment TNSS and TNN

关 键 词：真实世界 宣肺通窍针法 变应性鼻炎 

分 类 号：R276.521[医药卫生—中医五官科学]