中药靶向铁死亡干预糖尿病肾病基础研究进展  

Progress of Basic Research on the Intervention of TCM Targeted Ferroptosis in Diabetic Nephropathy

作　　者：李钦[1,2] 马仙康 朱向东 史晓伟 刘轩[2] 梁永林 LI Qin;MA Xiankang;ZHU Xiangdong;SHI Xiaowei;LIU Xuan;LIANG Yonglin(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Health Vocational College,Lanzhou 730030,China;Ningxia Medical University,Yinchuan 750001,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃卫生职业学院,甘肃兰州730030 [3]宁夏医科大学,宁夏银川750001 [4]甘肃省中医院,甘肃兰州730050

出　　处：《中国中医药信息杂志》2024年第6期181-186,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：甘肃省自然科学基金(22JR5RA810);甘肃省教育科技创新项目(2022A-249);宁夏自然科学基金重点项目(2023AAC02035);甘肃省高校教师创新基金项目(2023A-298)。

摘　　要：糖尿病肾病是糖尿病最严重的微血管病变之一,也是导致终末期肾病患者死亡的主要原因。铁死亡作为一种细胞程序性死亡模式,主要表现为细胞内脂质过氧化物及铁的过度累积。铁死亡参与糖尿病肾病肾足细胞、系膜细胞及肾小管上皮细胞损伤等一系列病理过程。中药治疗具有疗效显著、不良反应小等特点,已广泛用于糖尿病肾病防治。本文总结调节糖尿病肾病铁死亡的关键因子,以及靶向抑制铁死亡防治糖尿病肾病的中药活性成分及中药复方,为糖尿病肾病靶向药物研发提供参考。Diabetic nephropathy(DN)is one of the most serious microangiopathies in diabetes mellitus and the leading cause of death in patients with end-stage renal disease.Ferroptosis,as a mode of programmed cell death,is mainly manifested by excessive accumulation of intracellular lipid peroxides and iron.Ferroptosis is involved in a series of pathological processes such as damage to DN renal podocytes,mesangial cells,and renal tubular epithelial cells.Chinese materia medica has the characteristics of significant therapeutic effects and minimal adverse reactions in the treatment of diseases,and has been widely used in the prevention and treatment of DN.This article summarized the key factors regulating ferroptosis in DN,as well as the active components and TCM formulas targeting the inhibition of ferroptosis in the prevention and treatment of DN,providing reference for the development of DN targeted drugs.

关 键 词：糖尿病肾病 铁死亡 脂质过氧化物 中药 机制 综述 

分 类 号：R259.872[医药卫生—中西医结合]