Cross-species transmission and host range genes in poxviruses  

作　　者：Chen-Hui Yang A-Ling Song Ye Qiu Xing-Yi Ge 

机构地区：[1]College of Biology,Hunan Provincial Key Laboratory of Medical Virology,Hunan University,Changsha,410012,China

出　　处：《Virologica Sinica》2024年第2期177-193,共17页中国病毒学（英文版）

基　　金：funded by the National Natural Science Foundation of China(U2002218);the Hunan University Fund(521119400156).

摘　　要：The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread ofMPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-likesymptoms. MPXV belongs to the Poxviridae family, which has a relatively broad host range from arthropods tovertebrates. Cross-species transmission of poxviruses among different hosts has been frequently reported andresulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodeshundreds of proteins. Genes related to the host range of poxvirus are called host range genes (HRGs). This reviewbriefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes thecurrent knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus aredescribed and their impacts on viral host range are discussed in depth. We hope that this review will provide acomprehensive perspective about the current progress of researches on cross-species transmission and HRGvariation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.

关 键 词：POXVIRUS Host range gene(HRG) Host spectrum Cross-species transmission 

分 类 号：S852.65[农业科学—基础兽医学]