69例抗癫痫药物不良反应分析  

Analysis of 69 cases of adverse drug reactions of antiepileptic drugs

作　　者：周甜甜 张颖[1] 王录 ZHOU Tiantian;ZHANG Ying;WANG Lu(Department of Pharmacy,the Second People’s Hospital of Zhengzhou,Zhengzhou 450006,China)

机构地区：[1]郑州市第二人民医院药学部,郑州450006

出　　处：《上海医药》2024年第9期86-88,103,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：河南省医学科技攻关计划项目(2018020740)。

摘　　要：目的:了解抗癫痫药物不良反应(adverse drug reaction,ADR)的发生规律及特点。方法:提取我院上报至国家药品不良反应监测系统的抗癫痫药ADR报告进行分析。结果:共收集69例抗癫痫药ADR,涉及药品6种,包括丙戊酸钠、奥卡西平、卡马西平、拉莫三嗪、左乙拉西坦及苯妥英钠。ADR以神经系统最为常见,主要表现为头晕、嗜睡、头痛等,其次为肝胆、胃肠及代谢系统疾病。结论:临床应关注抗癫痫药ADR,加强用药监测。Objective:To understand the regularity and characteristics of adverse drug reaction(ADR)of antiepileptic drugs.Methods:All the ADRs of antiepileptic drugs reported by our hospital to the National ADR Monitoring System were extracted for analysis.Results:Sixty-nine ADRs of antiepileptic drugs were collected,involving 6 kinds of antiepileptic drugs,including sodium valproate,oxamazepine,carbamazepine,lamotrigine,levetiracetam and phenytoin sodium.Their most common manifestations involving in the nervous system were dizziness,drowsiness,headache and so on,followed by hepatobiliary,gastrointestinal and metabolic system diseases.Conclusion:Attention should be paid in clinic to the ADRs of antiepileptic drugs and the monitoring of antiepileptic drugs use should be strengthened.

关 键 词：抗癫痫药物 药物不良反应 分析 

分 类 号：R971.6[医药卫生—药品]