黄连素合成中缩合/还原反应甲基杂质的分离与二维核磁解析  

Isolation and 2D-NMR analysis of methylation impurity formed in the condensation/reduction reaction in the synthesis of berberine

作　　者：张祥明 赵宗敏 张小金 古志国 ZHANG Xiangming;ZHAO Zongmin;ZHANG Xiaojin;GU Zhiguo(Jiangxi Fushine Pharmaceutical Co.,Ltd.,Jingdezhen 333000,China)

机构地区：[1]江西富祥药业股份有限公司,景德镇333000

出　　处：《上海医药》2024年第9期118-121,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：黄连素是一种具有显著抑菌作用的重要生物碱。利用柱层析对其合成中缩合/还原反应甲基杂质进行分离,并用核磁氢谱^(1)H-NMR、碳谱^(13)C-NMR,二维核磁相关谱^(1)H-^(1)HCOSY、HSQC、HMBC以及DEPT135°对分离的甲基杂质进行了结构归属解析。Berberine is an important alkaloid with significant antibacterial effects.The methyl impurity in the condensation/reduction reaction during its synthesis was isolated by column chromatography and analyzed by ^(1)H-NMR,^(13)C-NMR,^(1)H-^(1)HCOSY,HSQC,HMBC and DEPT135°.

关 键 词：黄连素 杂质 柱层析 核磁共振二维谱解析 

分 类 号：O657.61[理学—分析化学] O623.738[理学—化学]